Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040039287> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2040039287 endingPage "146" @default.
- W2040039287 startingPage "140" @default.
- W2040039287 abstract "Metabolites of the amino acid tryptophan have been suspected of being involved in the genesis of human urinary bladder cancer. It was suggested that a neoplastic change could result from increased urinary excretion of tryptophan metabolites. From studies in which the excretion of metabolites was assessed after loading the patients with L-tryptophan it was concluded that abnormalities in tryptophan metabolism are causing the elevation of metabolite excretion. The present study however, which measured basal excretion of metabolites, demonstrates that the presence of tumor in the urinary tract must be considered as causative for elevations of metabolite excretion. An improved method for determining the spontaneous metabolite excretion is described. The metabolites kynurenine, kynurenic acid, 3-hydroxykynurenine, xanthurenic acid and 3-hydroxyanthranilic acid were determined in 165 urine samples obtained from bladder cancer patients, renal cancer patients, patients cured of bladder cancer and control subjects. Thirty six percent of the bladder cancer patients and 67% of the renal carcinoma patients excreted abnormally high amounts of at least one of the metabolites. It was observed that in bladder cancer an elevated excretion of metabolites occurred principally in patients with obstruction to the outflow of urine from the kidneys. Ureteral obstruction, probably a direct consequence of the presence of tumor in the urinary tract, causes an alteration in renal function which is reflected in urea and creatinine retention. The high incidence of abnormal excretion of tryptophan metabolites in renal cancer also points to alterations in renal function caused by the presence of tumor." @default.
- W2040039287 created "2016-06-24" @default.
- W2040039287 creator A5002287449 @default.
- W2040039287 creator A5014620513 @default.
- W2040039287 creator A5028100455 @default.
- W2040039287 creator A5057033879 @default.
- W2040039287 creator A5061193724 @default.
- W2040039287 creator A5065099078 @default.
- W2040039287 creator A5069964093 @default.
- W2040039287 date "1978-02-15" @default.
- W2040039287 modified "2023-09-27" @default.
- W2040039287 title "A new aspect of the urinary excretion of tryptophan metabolites in patients with cancer of the bladder" @default.
- W2040039287 cites W174034150 @default.
- W2040039287 cites W183543004 @default.
- W2040039287 cites W1904700104 @default.
- W2040039287 cites W1966273631 @default.
- W2040039287 cites W1978754363 @default.
- W2040039287 cites W2010710865 @default.
- W2040039287 cites W2045886024 @default.
- W2040039287 cites W2061765720 @default.
- W2040039287 cites W2092277246 @default.
- W2040039287 cites W2094388533 @default.
- W2040039287 cites W2278207774 @default.
- W2040039287 doi "https://doi.org/10.1002/ijc.2910210203" @default.
- W2040039287 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/627424" @default.
- W2040039287 hasPublicationYear "1978" @default.
- W2040039287 type Work @default.
- W2040039287 sameAs 2040039287 @default.
- W2040039287 citedByCount "22" @default.
- W2040039287 countsByYear W20400392872019 @default.
- W2040039287 countsByYear W20400392872020 @default.
- W2040039287 crossrefType "journal-article" @default.
- W2040039287 hasAuthorship W2040039287A5002287449 @default.
- W2040039287 hasAuthorship W2040039287A5014620513 @default.
- W2040039287 hasAuthorship W2040039287A5028100455 @default.
- W2040039287 hasAuthorship W2040039287A5057033879 @default.
- W2040039287 hasAuthorship W2040039287A5061193724 @default.
- W2040039287 hasAuthorship W2040039287A5065099078 @default.
- W2040039287 hasAuthorship W2040039287A5069964093 @default.
- W2040039287 hasConcept C10146269 @default.
- W2040039287 hasConcept C121608353 @default.
- W2040039287 hasConcept C126322002 @default.
- W2040039287 hasConcept C134018914 @default.
- W2040039287 hasConcept C185592680 @default.
- W2040039287 hasConcept C2776706248 @default.
- W2040039287 hasConcept C2777477808 @default.
- W2040039287 hasConcept C2777503454 @default.
- W2040039287 hasConcept C2780026642 @default.
- W2040039287 hasConcept C2780352672 @default.
- W2040039287 hasConcept C515207424 @default.
- W2040039287 hasConcept C55493867 @default.
- W2040039287 hasConcept C71924100 @default.
- W2040039287 hasConcept C77411442 @default.
- W2040039287 hasConceptScore W2040039287C10146269 @default.
- W2040039287 hasConceptScore W2040039287C121608353 @default.
- W2040039287 hasConceptScore W2040039287C126322002 @default.
- W2040039287 hasConceptScore W2040039287C134018914 @default.
- W2040039287 hasConceptScore W2040039287C185592680 @default.
- W2040039287 hasConceptScore W2040039287C2776706248 @default.
- W2040039287 hasConceptScore W2040039287C2777477808 @default.
- W2040039287 hasConceptScore W2040039287C2777503454 @default.
- W2040039287 hasConceptScore W2040039287C2780026642 @default.
- W2040039287 hasConceptScore W2040039287C2780352672 @default.
- W2040039287 hasConceptScore W2040039287C515207424 @default.
- W2040039287 hasConceptScore W2040039287C55493867 @default.
- W2040039287 hasConceptScore W2040039287C71924100 @default.
- W2040039287 hasConceptScore W2040039287C77411442 @default.
- W2040039287 hasIssue "2" @default.
- W2040039287 hasLocation W20400392871 @default.
- W2040039287 hasLocation W20400392872 @default.
- W2040039287 hasOpenAccess W2040039287 @default.
- W2040039287 hasPrimaryLocation W20400392871 @default.
- W2040039287 hasRelatedWork W1979515100 @default.
- W2040039287 hasRelatedWork W1991912276 @default.
- W2040039287 hasRelatedWork W2059373368 @default.
- W2040039287 hasRelatedWork W2093166709 @default.
- W2040039287 hasRelatedWork W2333543106 @default.
- W2040039287 hasRelatedWork W2396697385 @default.
- W2040039287 hasRelatedWork W2418199608 @default.
- W2040039287 hasRelatedWork W2473269187 @default.
- W2040039287 hasRelatedWork W2748952813 @default.
- W2040039287 hasRelatedWork W2802769072 @default.
- W2040039287 hasVolume "21" @default.
- W2040039287 isParatext "false" @default.
- W2040039287 isRetracted "false" @default.
- W2040039287 magId "2040039287" @default.
- W2040039287 workType "article" @default.