FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040040084> ?p ?o ?g. }

• W2040040084 endingPage "271" @default.
• W2040040084 startingPage "264" @default.
• W2040040084 abstract "When mice are exposed to harmless objects such as marbles in their cage they bury them, a behaviour sometimes known as defensive burying. We investigated the effect of an acute dose of MDMA (èecstasy') and other psychoactive drugs on marble burying and also examined the effect of a prior neurotoxic dose of MDMA or p-chloroamphetamine (PCA) on burying. Acute administration of MDMA produced dose-dependent inhibition of marble burying (EC50: 7.6 µ mol/kg). Other drugs that enhance monoamine function also produced dose-dependent inhibition: methamphetamine 〉 PCA 〉 paroxetine 〉 MDMA 〉 GBR 12909 〉 methylphenidate. None of these drugs altered locomotor activity at a dose that inhibited burying. A prior neurotoxic dose of MDMA, which decreased striatal dopamine content by 60%, but left striatal 5-HT content unaltered, did not alter spontaneous marble burying 18 or 40 days later. However, a neurotoxic dose of PCA which decreased striatal dopamine by 60% and striatal 5-HT by 70% attenuated marble burying 28 days later. Overall, these data suggest that MDMA, primarily by acutely increasing 5-HT function, acts like several anxiolytic drugs in this behavioural model. Long-term loss of cerebral 5-HT content also produced a similar effect. Since this change was observed only after 28 days, it is probably due to an adaptive response in the brain." @default.
• W2040040084 created "2016-06-24" @default.
• W2040040084 creator A5010253672 @default.
• W2040040084 creator A5020760522 @default.
• W2040040084 creator A5050626902 @default.
• W2040040084 creator A5089103988 @default.
• W2040040084 date "2006-03-01" @default.
• W2040040084 modified "2023-10-06" @default.
• W2040040084 title "The acute and long-term neurotoxic effects of MDMA on marble burying behaviour in mice" @default.
• W2040040084 cites W1968957681 @default.
• W2040040084 cites W1969750389 @default.
• W2040040084 cites W1970073509 @default.
• W2040040084 cites W1973743872 @default.
• W2040040084 cites W1982309599 @default.
• W2040040084 cites W1984757417 @default.
• W2040040084 cites W1990277146 @default.
• W2040040084 cites W1990580330 @default.
• W2040040084 cites W1993762893 @default.
• W2040040084 cites W1999445315 @default.
• W2040040084 cites W2000400042 @default.
• W2040040084 cites W2008388130 @default.
• W2040040084 cites W2013600778 @default.
• W2040040084 cites W2019924561 @default.
• W2040040084 cites W2024256764 @default.
• W2040040084 cites W2025546081 @default.
• W2040040084 cites W2039244923 @default.
• W2040040084 cites W2044165548 @default.
• W2040040084 cites W2045165986 @default.
• W2040040084 cites W2053714798 @default.
• W2040040084 cites W2057355532 @default.
• W2040040084 cites W2058842534 @default.
• W2040040084 cites W2064147241 @default.
• W2040040084 cites W2070128892 @default.
• W2040040084 cites W2075746070 @default.
• W2040040084 cites W2081349320 @default.
• W2040040084 cites W2082501508 @default.
• W2040040084 cites W2085124531 @default.
• W2040040084 cites W2090826913 @default.
• W2040040084 cites W2092456347 @default.
• W2040040084 cites W2092490886 @default.
• W2040040084 cites W2094043383 @default.
• W2040040084 cites W2094141023 @default.
• W2040040084 cites W2100352065 @default.
• W2040040084 cites W2110669693 @default.
• W2040040084 cites W2116488270 @default.
• W2040040084 cites W2117003509 @default.
• W2040040084 cites W2118909127 @default.
• W2040040084 cites W2124133878 @default.
• W2040040084 cites W2125082738 @default.
• W2040040084 cites W2132011757 @default.
• W2040040084 cites W2140244867 @default.
• W2040040084 cites W2155880922 @default.
• W2040040084 cites W2156537898 @default.
• W2040040084 cites W2158719307 @default.
• W2040040084 cites W2168069444 @default.
• W2040040084 doi "https://doi.org/10.1177/0269881106058022" @default.
• W2040040084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16510484" @default.
• W2040040084 hasPublicationYear "2006" @default.
• W2040040084 type Work @default.
• W2040040084 sameAs 2040040084 @default.
• W2040040084 citedByCount "13" @default.
• W2040040084 countsByYear W20400400842012 @default.
• W2040040084 countsByYear W20400400842015 @default.
• W2040040084 countsByYear W20400400842016 @default.
• W2040040084 countsByYear W20400400842018 @default.
• W2040040084 countsByYear W20400400842019 @default.
• W2040040084 countsByYear W20400400842020 @default.
• W2040040084 countsByYear W20400400842021 @default.
• W2040040084 countsByYear W20400400842022 @default.
• W2040040084 crossrefType "journal-article" @default.
• W2040040084 hasAuthorship W2040040084A5010253672 @default.
• W2040040084 hasAuthorship W2040040084A5020760522 @default.
• W2040040084 hasAuthorship W2040040084A5050626902 @default.
• W2040040084 hasAuthorship W2040040084A5089103988 @default.
• W2040040084 hasConcept C118552586 @default.
• W2040040084 hasConcept C124315065 @default.
• W2040040084 hasConcept C15744967 @default.
• W2040040084 hasConcept C169760540 @default.
• W2040040084 hasConcept C170493617 @default.
• W2040040084 hasConcept C185592680 @default.
• W2040040084 hasConcept C187714386 @default.
• W2040040084 hasConcept C2775864247 @default.
• W2040040084 hasConcept C2779488553 @default.
• W2040040084 hasConcept C2780376393 @default.
• W2040040084 hasConcept C2780876324 @default.
• W2040040084 hasConcept C42219234 @default.
• W2040040084 hasConcept C513476851 @default.
• W2040040084 hasConcept C55493867 @default.
• W2040040084 hasConcept C71924100 @default.
• W2040040084 hasConcept C98274493 @default.
• W2040040084 hasConceptScore W2040040084C118552586 @default.
• W2040040084 hasConceptScore W2040040084C124315065 @default.
• W2040040084 hasConceptScore W2040040084C15744967 @default.
• W2040040084 hasConceptScore W2040040084C169760540 @default.
• W2040040084 hasConceptScore W2040040084C170493617 @default.
• W2040040084 hasConceptScore W2040040084C185592680 @default.
• W2040040084 hasConceptScore W2040040084C187714386 @default.
• W2040040084 hasConceptScore W2040040084C2775864247 @default.

• next