Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040096258> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2040096258 endingPage "675" @default.
- W2040096258 startingPage "671" @default.
- W2040096258 abstract "Rhazya stricta leaves, which have both antidepressant and sedative properties in animal models, are widely used in folk medicine in the Arabian peninsula. In this study, the effects of oral administration of leaf extracts on rat brain tribulin levels [endogenous monoamine oxidase (MAO) A and B inhibitory activity], were determined. In an acute study, low doses brought about an increase in MAO A inhibitory activity, while intermediate doses caused a significant reduction. The highest doses had no significant effects on activity. There were no significant effects on MAO B inhibitory activity at any dose. Subchronic administration (21 days) caused a significant decrease in MAO A inhibitory activity, most prominent at low dosage, and an increase in MAO B inhibitory activity. Acute intramuscular administration also resulted in a similar pattern. Such paradoxical effects were at least partially explained when different extracts of the leaves were used; a weakly basic chloroform fraction caused an increase in MAO A inhibitory activity, whereas butanol extracts brought about a decrease. These fractions had no significant effects on MAO B inhibitory activity. The findings show that Rhazya stricta leaves contain at least two different components that affect MAO inhibitory activity in opposite directions. It may be that the antidepressant and sedative actions of the plant are explicable in terms of these different components." @default.
- W2040096258 created "2016-06-24" @default.
- W2040096258 creator A5004614263 @default.
- W2040096258 creator A5013294144 @default.
- W2040096258 creator A5021376217 @default.
- W2040096258 creator A5040926527 @default.
- W2040096258 creator A5066524696 @default.
- W2040096258 creator A5066560041 @default.
- W2040096258 creator A5088462454 @default.
- W2040096258 date "1998-03-01" @default.
- W2040096258 modified "2023-10-16" @default.
- W2040096258 title "Effect of Extract of Rhazya stricta, a Traditional Medicinal Plant, on Rat Brain Tribulin" @default.
- W2040096258 cites W1987412915 @default.
- W2040096258 cites W2005665072 @default.
- W2040096258 cites W2036337134 @default.
- W2040096258 cites W2083116805 @default.
- W2040096258 cites W2088205582 @default.
- W2040096258 cites W2157923688 @default.
- W2040096258 doi "https://doi.org/10.1016/s0091-3057(97)00464-4" @default.
- W2040096258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9512070" @default.
- W2040096258 hasPublicationYear "1998" @default.
- W2040096258 type Work @default.
- W2040096258 sameAs 2040096258 @default.
- W2040096258 citedByCount "22" @default.
- W2040096258 countsByYear W20400962582012 @default.
- W2040096258 countsByYear W20400962582016 @default.
- W2040096258 countsByYear W20400962582018 @default.
- W2040096258 countsByYear W20400962582020 @default.
- W2040096258 countsByYear W20400962582021 @default.
- W2040096258 countsByYear W20400962582022 @default.
- W2040096258 crossrefType "journal-article" @default.
- W2040096258 hasAuthorship W2040096258A5004614263 @default.
- W2040096258 hasAuthorship W2040096258A5013294144 @default.
- W2040096258 hasAuthorship W2040096258A5021376217 @default.
- W2040096258 hasAuthorship W2040096258A5040926527 @default.
- W2040096258 hasAuthorship W2040096258A5066524696 @default.
- W2040096258 hasAuthorship W2040096258A5066560041 @default.
- W2040096258 hasAuthorship W2040096258A5088462454 @default.
- W2040096258 hasConcept C116263406 @default.
- W2040096258 hasConcept C134018914 @default.
- W2040096258 hasConcept C17077164 @default.
- W2040096258 hasConcept C178790620 @default.
- W2040096258 hasConcept C181199279 @default.
- W2040096258 hasConcept C185592680 @default.
- W2040096258 hasConcept C2776024655 @default.
- W2040096258 hasConcept C2777602617 @default.
- W2040096258 hasConcept C2779177272 @default.
- W2040096258 hasConcept C2781161787 @default.
- W2040096258 hasConcept C29730261 @default.
- W2040096258 hasConcept C55493867 @default.
- W2040096258 hasConcept C556039675 @default.
- W2040096258 hasConcept C71924100 @default.
- W2040096258 hasConcept C86803240 @default.
- W2040096258 hasConcept C98274493 @default.
- W2040096258 hasConceptScore W2040096258C116263406 @default.
- W2040096258 hasConceptScore W2040096258C134018914 @default.
- W2040096258 hasConceptScore W2040096258C17077164 @default.
- W2040096258 hasConceptScore W2040096258C178790620 @default.
- W2040096258 hasConceptScore W2040096258C181199279 @default.
- W2040096258 hasConceptScore W2040096258C185592680 @default.
- W2040096258 hasConceptScore W2040096258C2776024655 @default.
- W2040096258 hasConceptScore W2040096258C2777602617 @default.
- W2040096258 hasConceptScore W2040096258C2779177272 @default.
- W2040096258 hasConceptScore W2040096258C2781161787 @default.
- W2040096258 hasConceptScore W2040096258C29730261 @default.
- W2040096258 hasConceptScore W2040096258C55493867 @default.
- W2040096258 hasConceptScore W2040096258C556039675 @default.
- W2040096258 hasConceptScore W2040096258C71924100 @default.
- W2040096258 hasConceptScore W2040096258C86803240 @default.
- W2040096258 hasConceptScore W2040096258C98274493 @default.
- W2040096258 hasIssue "3" @default.
- W2040096258 hasLocation W20400962581 @default.
- W2040096258 hasLocation W20400962582 @default.
- W2040096258 hasOpenAccess W2040096258 @default.
- W2040096258 hasPrimaryLocation W20400962581 @default.
- W2040096258 hasRelatedWork W2008009563 @default.
- W2040096258 hasRelatedWork W2040096258 @default.
- W2040096258 hasRelatedWork W2314468284 @default.
- W2040096258 hasRelatedWork W2396860618 @default.
- W2040096258 hasRelatedWork W2411938550 @default.
- W2040096258 hasRelatedWork W2414453160 @default.
- W2040096258 hasRelatedWork W2945151606 @default.
- W2040096258 hasRelatedWork W3087591478 @default.
- W2040096258 hasRelatedWork W3130638756 @default.
- W2040096258 hasRelatedWork W3201248417 @default.
- W2040096258 hasVolume "59" @default.
- W2040096258 isParatext "false" @default.
- W2040096258 isRetracted "false" @default.
- W2040096258 magId "2040096258" @default.
- W2040096258 workType "article" @default.