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• W2040097789 abstract "This prospective cross-sectional study was conducted to clarify whether serum cystatin C levels might be associated with not only arterial stiffness, but also the pressure wave reflection, in middle-aged Japanese subjects with normal renal function or mild chronic kidney disease (CKD) (stage 1 or 2 CKD) (i.e., creatinine-based estimate of the glomerular filtration rate (eGFRcr) ≥60ml/min/1.73m2 plus a result of the urine dipstick test for proteinuria of <1+). In 2,904 Japanese subjects (45 ± 9 years old), the brachial–ankle pulse wave velocity (baPWV), radial augmentation index adjusted to a heart rate of 75beats/min (rAI75), and serum cystatin C levels were measured. Multivariate linear regression analysis demonstrated that the serum cystatin C levels were significantly correlated with the baPWV (standardized coefficient = 0.04, P < 0.01) even after adjustments for confounding variables, but not with the AI75 (standardized coefficient = 0.01, P = 0.71). adjusted values of the baPWV, but not those of rAI75, were higher in subjects with serum cystatin C levels in the highest tertile than in those with serum cystatin levels in the intermediate or lowest tertile. In middle-aged Japanese subjects with normal renal function or mild CKD (stage 1 or 2 CKD) (eGFRcr >60ml/min/1.73m2 plus a result of the urine dipstick test for proteinuria of <1+), the serum cystatin C levels may reflect facet of cardiovascular risk associated with arterial stiffness, but not that associated with the pressure wave reflection." @default.
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• W2040097789 date "2010-09-01" @default.
• W2040097789 modified "2023-09-24" @default.
• W2040097789 title "Association of Serum Cystatin C With Pulse Wave Velocity, But Not Pressure Wave Reflection, in Subjects With Normal Renal Function or Mild Chronic Kidney Disease" @default.
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• W2040097789 doi "https://doi.org/10.1038/ajh.2010.100" @default.
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