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- W2040097804 abstract "Estrogen receptors (ERs) and the aryl hydrocarbon receptor (AhR) are ligand activated transcription factors and members of the nuclear receptor and bHLH-PAS superfamilies, respectively. AhR is involved in xenobiotic metabolism and in mediating the toxic effects of dioxin-like compounds. Crosstalk has been observed among AhR and nuclear receptors, but has been most well studied with respect to ER signaling. Activated AhR inhibits ER activity through a number of different mechanisms, whereas ERα has been reported to have a positive role in AhR signaling. Here we will discuss recent data revealing that dioxin bound AhR recruits ERα to AhR regulated genes. We will also consider the implications of ER recruitment to AhR target genes on ER and AhR signaling." @default.
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- W2040097804 date "2006-01-01" @default.
- W2040097804 modified "2023-10-12" @default.
- W2040097804 title "Estrogen receptor and aryl hydrocarbon receptor signaling pathways" @default.
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- W2040097804 doi "https://doi.org/10.1621/nrs.04016" @default.
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