FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040100208> ?p ?o ?g. }

• W2040100208 endingPage "431" @default.
• W2040100208 startingPage "423" @default.
• W2040100208 abstract "Eimeria bovis is an important coccidian parasite of cattle causing severe diarrhea in young animals. Its first schizogony takes place in endothelial cells of the ileum resulting in the formation of macroschizonts 14–18 days p.i. This longlasting development suggests a particular immune evasion strategy of the parasite. Here, we analyse early innate immune reactions to E. bovis by determining the adhesion of polymorphonuclear neutrophils (PMN) to infected endothelial cell layers under flow conditions and the transcription of adhesion molecule genes in infected host cells. Bovine umbilical vein endothelial cells (BUVEC) were infected with E. bovis sporozoites. Sporozoites invaded BUVEC within 1 h and the first mature macroschizonts occurred 14 days p.i. PMN adhesion was enhanced in E. bovis-infected BUVEC layers as early as 8 h p.i.; maximum adhesion occurred 48 h p.i. Increased adhesion rates persisted until the end of the observation period at 14 days p.i. PMN adhered to both infected and uninfected cells within monolayers, suggesting paracrine cell activation. E. bovis infection upregulated the transcription of genes encoding for P-selectin, E-selectin, vascular cellular adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1). Most marked effects concerned E-selectin followed by P-selectin, VCAM-1 and ICAM-1. Increased transcript levels were found beginning 30 min p.i. and maximum values occurred 1–2 h p.i. (P-selectin) and 2–4 h p.i. (E-selectin, VCAM-1, ICAM-1). By 12–24 h p.i. levels had decreased to those of uninfected controls. Tumor necrosis factor α (TNFα)-induced PMN adhesion was significantly reduced in infected vs. uninfected BUVEC. Eimeria bovis also had suppressive effects on TNFα-mediated upregulation of adhesion molecule gene transcription. The data presented here suggest that infection of BUVEC with E. bovis on one hand induces proinflammatory reactions resulting in enhanced PMN adhesion mediated by upregulated adhesion molecule gene transcription but on the other downregulates TNFα-induced cell activation." @default.
• W2040100208 created "2016-06-24" @default.
• W2040100208 creator A5031802999 @default.
• W2040100208 creator A5033993389 @default.
• W2040100208 creator A5045679978 @default.
• W2040100208 date "2006-04-01" @default.
• W2040100208 modified "2023-10-17" @default.
• W2040100208 title "Eimeria bovis modulates adhesion molecule gene transcription in and PMN adhesion to infected bovine endothelial cells" @default.
• W2040100208 cites W120000674 @default.
• W2040100208 cites W137274086 @default.
• W2040100208 cites W1485550654 @default.
• W2040100208 cites W1666876313 @default.
• W2040100208 cites W1916213760 @default.
• W2040100208 cites W1922238816 @default.
• W2040100208 cites W1942966726 @default.
• W2040100208 cites W1965836015 @default.
• W2040100208 cites W1979074659 @default.
• W2040100208 cites W1988158625 @default.
• W2040100208 cites W1988219720 @default.
• W2040100208 cites W1993814898 @default.
• W2040100208 cites W2003915858 @default.
• W2040100208 cites W2003984322 @default.
• W2040100208 cites W2027089742 @default.
• W2040100208 cites W2029631026 @default.
• W2040100208 cites W2031711113 @default.
• W2040100208 cites W2032371793 @default.
• W2040100208 cites W2033437855 @default.
• W2040100208 cites W2040333940 @default.
• W2040100208 cites W2050632232 @default.
• W2040100208 cites W2059722558 @default.
• W2040100208 cites W2072437217 @default.
• W2040100208 cites W2075836508 @default.
• W2040100208 cites W2098301173 @default.
• W2040100208 cites W2124101784 @default.
• W2040100208 cites W2124801539 @default.
• W2040100208 cites W2126901007 @default.
• W2040100208 cites W2127953000 @default.
• W2040100208 cites W2129525366 @default.
• W2040100208 cites W2130397039 @default.
• W2040100208 cites W2142346251 @default.
• W2040100208 cites W2152315492 @default.
• W2040100208 cites W2157603347 @default.
• W2040100208 cites W2170337377 @default.
• W2040100208 cites W2314658785 @default.
• W2040100208 cites W2317382314 @default.
• W2040100208 cites W2400954299 @default.
• W2040100208 cites W4313306020 @default.
• W2040100208 cites W4313422296 @default.
• W2040100208 doi "https://doi.org/10.1016/j.ijpara.2006.01.001" @default.
• W2040100208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16500654" @default.
• W2040100208 hasPublicationYear "2006" @default.
• W2040100208 type Work @default.
• W2040100208 sameAs 2040100208 @default.
• W2040100208 citedByCount "48" @default.
• W2040100208 countsByYear W20401002082012 @default.
• W2040100208 countsByYear W20401002082014 @default.
• W2040100208 countsByYear W20401002082015 @default.
• W2040100208 countsByYear W20401002082016 @default.
• W2040100208 countsByYear W20401002082017 @default.
• W2040100208 countsByYear W20401002082018 @default.
• W2040100208 countsByYear W20401002082019 @default.
• W2040100208 countsByYear W20401002082020 @default.
• W2040100208 countsByYear W20401002082021 @default.
• W2040100208 countsByYear W20401002082022 @default.
• W2040100208 countsByYear W20401002082023 @default.
• W2040100208 crossrefType "journal-article" @default.
• W2040100208 hasAuthorship W2040100208A5031802999 @default.
• W2040100208 hasAuthorship W2040100208A5033993389 @default.
• W2040100208 hasAuthorship W2040100208A5045679978 @default.
• W2040100208 hasBestOaLocation W20401002082 @default.
• W2040100208 hasConcept C1491633281 @default.
• W2040100208 hasConcept C153911025 @default.
• W2040100208 hasConcept C155619193 @default.
• W2040100208 hasConcept C16224149 @default.
• W2040100208 hasConcept C199616788 @default.
• W2040100208 hasConcept C203014093 @default.
• W2040100208 hasConcept C2909375385 @default.
• W2040100208 hasConcept C55493867 @default.
• W2040100208 hasConcept C85789140 @default.
• W2040100208 hasConcept C86803240 @default.
• W2040100208 hasConcept C8891405 @default.
• W2040100208 hasConcept C95444343 @default.
• W2040100208 hasConceptScore W2040100208C1491633281 @default.
• W2040100208 hasConceptScore W2040100208C153911025 @default.
• W2040100208 hasConceptScore W2040100208C155619193 @default.
• W2040100208 hasConceptScore W2040100208C16224149 @default.
• W2040100208 hasConceptScore W2040100208C199616788 @default.
• W2040100208 hasConceptScore W2040100208C203014093 @default.
• W2040100208 hasConceptScore W2040100208C2909375385 @default.
• W2040100208 hasConceptScore W2040100208C55493867 @default.
• W2040100208 hasConceptScore W2040100208C85789140 @default.
• W2040100208 hasConceptScore W2040100208C86803240 @default.
• W2040100208 hasConceptScore W2040100208C8891405 @default.
• W2040100208 hasConceptScore W2040100208C95444343 @default.
• W2040100208 hasIssue "4" @default.
• W2040100208 hasLocation W20401002081 @default.
• W2040100208 hasLocation W20401002082 @default.
• W2040100208 hasLocation W20401002083 @default.

• next