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• W2040109946 abstract "Definir un modelo experimental de shock séptico que pueda aplicarse al entrenamiento en el manejo inicial del shock séptico, de forma concreta mediante el uso de técnicas de depuración extrarrenal (TDE). Estudio experimental de casos-control. Hospital veterinario universitario. Diez perros Beagle (peso 12-15 kg). Se provocó shock infundiendo 1 mg/kg de lipopolisacárido de Escherichia coli (LPS) en 20 ml salino en 10 min, con un seguimiento posterior de 6 h. Cinco animales no recibieron intervención para definir el curso del shock y 5 fueron tratados con hemofiltración de alto volumen (HVHF, 100 ml/kg/h) para valorar la rapidez de respuesta. Se monitorizaron presiones (arterial y pulmonar), parámetros hemodinámicos, tonometría gástrica y función respiratoria. A los 2 min el efecto de la infusión de LPS era apreciable y al final de la infusión los 10 animales mostraban shock severo. A las 2 h se apreciaban diferencias en gasto cardíaco, variabilidad de volumen sistólico y CO2 mucoso entre tratados y no tratados. En 4 h la diferencia era evidente también en presión arterial media. Ningún control y todos los tratados sobrevivieron las 6 h del experimento. Posteriormente, hemos desarrollado un taller docente basado en este protocolo que se ha aplicado en cinco cursos de formación (www.ccmijesususon.com; www.crrtcordoba.com.es/), obteniendo los resultados previstos. Este modelo de shock muestra una respuesta predecible en el tiempo, una latencia muy corta y una mejoría en animales tratados suficientemente rápida como para aplicarlo en talleres de formación. Es útil para el entrenamiento en HVHF y, asimismo, podría aplicarse en otros escenarios de manejo precoz del shock séptico. To define a septic shock experimental model that can be used in for training in the early management of septic shock, specifically by extracorporeal depuration (ECD). A case-control experimental study. Veterinary university hospital. Ten Beagle dogs (weight 12-15 kg). Shock was induced using 1 mg/kg Escherichia coli lipopolysaccharide (LPS) diluted in 20 mL saline infused in 10 minutes, with a subsequent follow-up at 6 hours. There was no intervention in 5 animals in order to define the natural course of the shock and 5 underwent high volume hemofiltration (HVHF, 100 mL/kg/h) to define delay in response to treatment. Pressures (arterial and pulmonary), hemodynamic parameters, gastric tonometry and respiratory function were recorded. The LPS effect was evidenced at 2 minutes of the infusion and the 10 animals showed severe shock at the end of the infusion. At 2-hours, changes between treated and non-treated animals were seen in cardiac output, systolic volume variability and mucous CO2. Mean arterial pressure was significantly different at four hours. All non-treated subjects died during the 6-hour follow-up and all the treated animals survived for this period. Based on these results, we developed a workshop that has been used in five courses (www.ccmijesususon.com – www.crrtcordoba.com.es/), obtaining the previous results. Our shock model shows a predictable behavior, very short latency and a sufficiently rapid improvement in the treated animals for it to be applied in training workshops. It is useful for training in the high-volume hemofilitration (HVHF) and can be used for training in the early management of septic shock." @default.
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• W2040109946 date "2011-03-01" @default.
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• W2040109946 title "Desarrollo de un modelo experimental de shock séptico orientado a la formación. Aplicación en el entrenamiento de técnicas de depuración en el manejo de la sepsis grave" @default.
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• W2040109946 doi "https://doi.org/10.1016/j.medin.2010.12.011" @default.
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