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- W2040110543 abstract "Over the last three decades, there have been remarkable advances in percutaneous coronary intervention (PCI). Utilization of coronary stents and combination antiplatelet/antithrombotic therapy have led to significant improvements in revascularization success rates as well as marked reductions in thrombotic complications. Patients considering elective procedures are now routinely quoted a 800 000 PCI procedures are performed annually in Europe.1 In addition, PCI is being performed in increasingly complex patients, including the elderly and those with multiple co-morbidities, who are at higher risk for incurring procedural complications.However, with increased utilization of PCI, increased use of combinations of multiple antithrombotic agents, and the reduction in the occurrence of ischaemic/thrombotic complications of PCI, there has emerged recognition that post-procedural bleeding complications remain all too common and result in significant morbidity and mortality. In a retrospective analysis of >10 000 patients undergoing PCI at a single centre between 1991 and 2000, major bleeding occurred in 5.4% of patients and was associated with a 3.5-fold increased adjusted risk of in-hospital mortality.2 Similarly, in an analysis of >24 000 patients with acute coronary syndromes enrolled in the Global Registry of Acute Coronary Events (GRACE), major bleeding occurred in 5.5% of patients undergoing PCI and was associated with a significant increase in hospital death.3 Finally, it has been estimated that the incremental cost of prolonged hospitalization and treatment associated with bleeding complications exceeds US$10 000/hospital stay. … *Corresponding author. Tel: +33 1 40 25 86 68. E-mail address : gabriel.steg{at}bch.aphp.fr" @default.
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- W2040110543 date "2007-02-06" @default.
- W2040110543 modified "2023-10-01" @default.
- W2040110543 title "Major bleeding after PCI. Where is our crystal ball?" @default.
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- W2040110543 doi "https://doi.org/10.1093/eurheartj/ehm265" @default.
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