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- W2040117967 abstract "Downregulation of pro-inflammatory events in the immune response to Mycobacterium tuberculosis is critical to prevent host tissue injury. Interleukin (IL-)10 is an important anti-inflammatory cytokine secreted in human tuberculosis but little is known about the control of such IL-10 release. Using an established cellular model, we measured IL-10 secretion after phagocytosis of M. tuberculosis. Phagocytosis of M. tuberculosis but not of inert latex beads by human monocytic (THP-1) cells resulted in IL-10 secretion maximal at 24 h. The magnitude and kinetics of IL-10 secretion were distinct from IL-10 secretion after phagocytosis of yeast-derived zymosan and depended on transcriptional activity and protein synthesis in infected monocytes. IL-10 secretion was decreased in a dose-dependent manner by specific inhibitors of tyrosine kinases, protein kinase (PK) C and PKA. Inhibition of more than one pathway did not result in further synergistic or additive reduction in IL-10 secretion. Finally, specific neutralising antibody directed against IL-10 demonstrated that IL-10 secreted by infected monocytic cells did not block autologous IL-8 secretion." @default.
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- W2040117967 date "2000-05-01" @default.
- W2040117967 modified "2023-09-27" @default.
- W2040117967 title "REGULATION OF IL-10 SECRETION AFTER PHAGOCYTOSIS OF MYCOBACTERIUM TUBERCULOSIS BY HUMAN MONOCYTIC CELLS" @default.
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- W2040117967 doi "https://doi.org/10.1006/cyto.1999.0586" @default.
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