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• W2040151070 abstract "The experimental sections of this study have demonstrated that neonatal guinea pigs injected with homologous testicular homogenate combined with adjuvant undergo aspermatogenesis after they reach maturity. Sensitization thus occurs early and there is an early release of circulating body. Seminiferous differentiation and spermatogenesis, however, are neither inhibited nor prevented, but testicular destruction follows later. Both testes of a pair tend to respond alike as to timing and severity of lesions; unilateral castration during neonatal or adolescent stages has no effect on the aspermatogenic response of the remaining testis. Histologically normal testes, removed from sensitized animals, induce aspermatogenesis and the release of circulating antibody in mature recipients, but damaged testes from sensitized animals fail to do so. The sequence of events in a single animal can be studied by semicastration at an early stage and examination of the remaining testis later on. No granulomatous lesions or perivascular leucocytic infiltration characterize the early stages. One of the first abnormal findings is the filling of epididymal ducts with cellular debris sloughed from the germinal epithelium. The antigenic material is limited to the adult testis, containing spermatids and spermatozoa which give the staining reactions of polysaccharides. Neonatal testes fail to induce aspermatogenesis when injected into adult guinea pigs. In the discussion, conditions are noted under which aspermatogenesis is induced without previous combination of antigen and adjuvant at the site of injection. Neonatal guinea pigs are immunologically competent, as judged by their capacity to produce humoral antibody during the first week after birth. Immune tolerance, to be acquired by guinea pigs, must thus be induced in utero. An attempt has been made to relate these findings to the sequence of events involved in aspermatogenesis. The evidence supports the recognition hypothesis of Burnet and Fenner, and further suggests that antigen modification need not be a requirement of autoantigenicity. It is postulated that different types of immunologic competence develop in sequence in young animals. The characteristics of the aspermatogenic syndrome in relation to homograft rejection are briefly discussed." @default.
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• W2040151070 date "1961-08-01" @default.
• W2040151070 modified "2023-10-02" @default.
• W2040151070 title "Induced aspermatogenesis in adult guinea pigs injected with testicular antigen and adjuvant in neonatal stages" @default.
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• W2040151070 doi "https://doi.org/10.1016/0012-1606(61)90028-8" @default.
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