FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040157712> ?p ?o ?g. }

• W2040157712 endingPage "743" @default.
• W2040157712 startingPage "736" @default.
• W2040157712 abstract "Over 10% of Crohn's disease (CD) patients annually lose response to infliximab. Infliximab trough levels (TL), concomitant immunosuppressants and endoscopic healing were proposed as predictors of favourable infliximab outcome. We assessed infliximab TL measured after induction therapy as predictors of sustained clinical response. Furthermore, we tried to identify other predictors of long-term benefit of infliximab therapy.We included CD patients treated with infliximab between October 2007 and March 2010 who responded to 3-dose induction followed by maintenance therapy and in whom blood samples taken at treatment week 14 or 22 were available in blood bank. Sustained response to infliximab was defined as absence of treatment failure due to loss of response or drug intolerance.Eighty four patients were included. Sustained response to infliximab was observed in 47 (56%) patients during a median follow-up of 25 months (14-37). Infliximab TL>3μg/ml were associated with a decreased risk of treatment failure (HR 0.34; 95% CI: 0.16-0.75), whereas the presence of antibodies against infliximab and need for corticosteroids increased this risk (HR 4.34; 95% CI: 1.51-12.5 and HR 2.49, 95% CI: 1.08-5.73, respectively). No impact of concomitant thiopurines was observed, although patients receiving thiopurines had higher infliximab TL than those without immunomodulators (5.51 vs. 0.71μg/ml; p=0.01).During a median follow up of 2 years sustained response to infliximab was observed in slightly more than half of CD patients. Infliximab TL>3μg/ml at the start of maintenance regime were predicative of sustained response to infliximab." @default.
• W2040157712 created "2016-06-24" @default.
• W2040157712 creator A5015033532 @default.
• W2040157712 creator A5015325934 @default.
• W2040157712 creator A5026791082 @default.
• W2040157712 creator A5032177730 @default.
• W2040157712 creator A5035894364 @default.
• W2040157712 creator A5074210541 @default.
• W2040157712 creator A5075611998 @default.
• W2040157712 creator A5085176483 @default.
• W2040157712 date "2013-10-01" @default.
• W2040157712 modified "2023-09-25" @default.
• W2040157712 title "Infliximab trough levels may predict sustained response to infliximab in patients with Crohn's disease" @default.
• W2040157712 cites W1536336065 @default.
• W2040157712 cites W1965832974 @default.
• W2040157712 cites W2003904406 @default.
• W2040157712 cites W2020350753 @default.
• W2040157712 cites W2020710276 @default.
• W2040157712 cites W2043261411 @default.
• W2040157712 cites W2056596058 @default.
• W2040157712 cites W2059127937 @default.
• W2040157712 cites W2071353820 @default.
• W2040157712 cites W2079185331 @default.
• W2040157712 cites W2080037503 @default.
• W2040157712 cites W2081071002 @default.
• W2040157712 cites W2093504865 @default.
• W2040157712 cites W2118088660 @default.
• W2040157712 cites W2118559127 @default.
• W2040157712 cites W2126807394 @default.
• W2040157712 cites W2128694968 @default.
• W2040157712 cites W2145436896 @default.
• W2040157712 cites W2146963207 @default.
• W2040157712 cites W2171341132 @default.
• W2040157712 cites W2326330820 @default.
• W2040157712 cites W2615184173 @default.
• W2040157712 doi "https://doi.org/10.1016/j.crohns.2012.10.019" @default.
• W2040157712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23200919" @default.
• W2040157712 hasPublicationYear "2013" @default.
• W2040157712 type Work @default.
• W2040157712 sameAs 2040157712 @default.
• W2040157712 citedByCount "208" @default.
• W2040157712 countsByYear W20401577122013 @default.
• W2040157712 countsByYear W20401577122014 @default.
• W2040157712 countsByYear W20401577122015 @default.
• W2040157712 countsByYear W20401577122016 @default.
• W2040157712 countsByYear W20401577122017 @default.
• W2040157712 countsByYear W20401577122018 @default.
• W2040157712 countsByYear W20401577122019 @default.
• W2040157712 countsByYear W20401577122020 @default.
• W2040157712 countsByYear W20401577122021 @default.
• W2040157712 countsByYear W20401577122022 @default.
• W2040157712 countsByYear W20401577122023 @default.
• W2040157712 crossrefType "journal-article" @default.
• W2040157712 hasAuthorship W2040157712A5015033532 @default.
• W2040157712 hasAuthorship W2040157712A5015325934 @default.
• W2040157712 hasAuthorship W2040157712A5026791082 @default.
• W2040157712 hasAuthorship W2040157712A5032177730 @default.
• W2040157712 hasAuthorship W2040157712A5035894364 @default.
• W2040157712 hasAuthorship W2040157712A5074210541 @default.
• W2040157712 hasAuthorship W2040157712A5075611998 @default.
• W2040157712 hasAuthorship W2040157712A5085176483 @default.
• W2040157712 hasConcept C126322002 @default.
• W2040157712 hasConcept C141071460 @default.
• W2040157712 hasConcept C2776694085 @default.
• W2040157712 hasConcept C2777138892 @default.
• W2040157712 hasConcept C2778283404 @default.
• W2040157712 hasConcept C2779134260 @default.
• W2040157712 hasConcept C2779280984 @default.
• W2040157712 hasConcept C2779384505 @default.
• W2040157712 hasConcept C71924100 @default.
• W2040157712 hasConcept C90924648 @default.
• W2040157712 hasConceptScore W2040157712C126322002 @default.
• W2040157712 hasConceptScore W2040157712C141071460 @default.
• W2040157712 hasConceptScore W2040157712C2776694085 @default.
• W2040157712 hasConceptScore W2040157712C2777138892 @default.
• W2040157712 hasConceptScore W2040157712C2778283404 @default.
• W2040157712 hasConceptScore W2040157712C2779134260 @default.
• W2040157712 hasConceptScore W2040157712C2779280984 @default.
• W2040157712 hasConceptScore W2040157712C2779384505 @default.
• W2040157712 hasConceptScore W2040157712C71924100 @default.
• W2040157712 hasConceptScore W2040157712C90924648 @default.
• W2040157712 hasIssue "9" @default.
• W2040157712 hasLocation W20401577121 @default.
• W2040157712 hasLocation W20401577122 @default.
• W2040157712 hasOpenAccess W2040157712 @default.
• W2040157712 hasPrimaryLocation W20401577121 @default.
• W2040157712 hasRelatedWork W1542252223 @default.
• W2040157712 hasRelatedWork W2006318665 @default.
• W2040157712 hasRelatedWork W2009454193 @default.
• W2040157712 hasRelatedWork W2026116536 @default.
• W2040157712 hasRelatedWork W2032015456 @default.
• W2040157712 hasRelatedWork W2032850606 @default.
• W2040157712 hasRelatedWork W2068295140 @default.
• W2040157712 hasRelatedWork W2161452915 @default.
• W2040157712 hasRelatedWork W2320335540 @default.
• W2040157712 hasRelatedWork W2999807194 @default.
• W2040157712 hasVolume "7" @default.
• W2040157712 isParatext "false" @default.

• next