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• W2040157836 abstract "Diabetes mellitus is a group of complicated metabolic disorders characterized by high blood glucose level and inappropriate insulin secreting capacity due to decreased glucose metabolism and pancreatic β cell mass or dysfunction of β cells. Thus, improving glucose metabolism and preserving β cell mass and function might be useful for the treatment of diabetes. In this study, a novel acidic polysaccharide LBP-s-1 extracted from Lycium barbarum L. was obtained by purification using macroporous resin and ion-exchanged column. Monosaccharide composition analysis indicated that LBP-s-1 was comprised of rhamnose, arabinose, xylose, mannose, glucose, galactose, galacturonic acid in the molar ratio of 1.00:8.34:1.25:1.26:1.91:7.05:15.28. The preliminary structure features of LBP-s-1 were investigated by FT-IR, 1H NMR and 13C NMR. In vitro and in vivo hypoglycemic experiments showed that LBP-s-1 had significant hypoglycemic effects and insulin-sensitizing activity through increasing glucose metabolism and insulin secretion and promoting pancreatic β cell proliferation. Preliminary mechanisms were also elucidated." @default.
• W2040157836 created "2016-06-24" @default.
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• W2040157836 date "2013-10-01" @default.
• W2040157836 modified "2023-10-16" @default.
• W2040157836 title "Characterization and hypoglycemic effect of a polysaccharide extracted from the fruit of Lycium barbarum L." @default.
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• W2040157836 doi "https://doi.org/10.1016/j.carbpol.2013.04.057" @default.
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