Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040172690> ?p ?o ?g. }
- W2040172690 endingPage "279" @default.
- W2040172690 startingPage "271" @default.
- W2040172690 abstract "Background: Prolonged induction of excessive levels of inflammatory mediators contributes to the pathogenesis of chronic disease states, such as periodontitis. It is thus important to develop safe and effective anti‐inflammatory strategies for therapeutic reasons. In this study, we determined the ability of aqueous extracts from elder flower ( Sambucus nigra ) to inhibit the proinflammatory activity of major virulence factors from the periodontal pathogens Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans . Methods: Monocytes/macrophages or neutrophils were incubated with whole cells of P. gingivalis , A. actinomycetemcomitans , or purified components thereof (lipopolysaccharide and fimbriae) in the absence or presence of elder flower extract and were assayed for cytokine production, integrin activation, or induction of the oxidative burst. Results: The elder flower extract was found to potently inhibit all proinflammatory activities tested. Investigation of the underlying mechanisms revealed that the anti‐inflammatory extract inhibited activation of the nuclear transcription factor κB and of phosphatidylinositol 3‐kinase. Conclusion: The elder flower extract displays useful anti‐inflammatory properties that could be exploited therapeutically for the control of inflammation in human periodontitis." @default.
- W2040172690 created "2016-06-24" @default.
- W2040172690 creator A5053943358 @default.
- W2040172690 creator A5062271003 @default.
- W2040172690 creator A5063628247 @default.
- W2040172690 creator A5075008449 @default.
- W2040172690 creator A5084031628 @default.
- W2040172690 date "2006-02-01" @default.
- W2040172690 modified "2023-09-27" @default.
- W2040172690 title "Inhibition of Proinflammatory Activities of Major Periodontal Pathogens by Aqueous Extracts From Elder Flower (<i>Sambucus nigra</i>)" @default.
- W2040172690 cites W10482017 @default.
- W2040172690 cites W1496738787 @default.
- W2040172690 cites W1529396499 @default.
- W2040172690 cites W1754891924 @default.
- W2040172690 cites W1934775191 @default.
- W2040172690 cites W1960939533 @default.
- W2040172690 cites W1966391340 @default.
- W2040172690 cites W1979580921 @default.
- W2040172690 cites W1981077894 @default.
- W2040172690 cites W1986823542 @default.
- W2040172690 cites W2002293674 @default.
- W2040172690 cites W2006446093 @default.
- W2040172690 cites W2013144840 @default.
- W2040172690 cites W2017899449 @default.
- W2040172690 cites W2036932056 @default.
- W2040172690 cites W2049970827 @default.
- W2040172690 cites W2053344942 @default.
- W2040172690 cites W2063890754 @default.
- W2040172690 cites W2064338048 @default.
- W2040172690 cites W2065395115 @default.
- W2040172690 cites W2068933786 @default.
- W2040172690 cites W2074758557 @default.
- W2040172690 cites W2079925343 @default.
- W2040172690 cites W2095732393 @default.
- W2040172690 cites W2108985104 @default.
- W2040172690 cites W2113084599 @default.
- W2040172690 cites W2121515004 @default.
- W2040172690 cites W2133664523 @default.
- W2040172690 cites W2138188253 @default.
- W2040172690 cites W2142644251 @default.
- W2040172690 cites W2149150753 @default.
- W2040172690 cites W2152096613 @default.
- W2040172690 cites W2158754447 @default.
- W2040172690 cites W2163856183 @default.
- W2040172690 cites W2173541155 @default.
- W2040172690 cites W4236842068 @default.
- W2040172690 doi "https://doi.org/10.1902/jop.2006.050232" @default.
- W2040172690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16460254" @default.
- W2040172690 hasPublicationYear "2006" @default.
- W2040172690 type Work @default.
- W2040172690 sameAs 2040172690 @default.
- W2040172690 citedByCount "61" @default.
- W2040172690 countsByYear W20401726902012 @default.
- W2040172690 countsByYear W20401726902013 @default.
- W2040172690 countsByYear W20401726902014 @default.
- W2040172690 countsByYear W20401726902015 @default.
- W2040172690 countsByYear W20401726902016 @default.
- W2040172690 countsByYear W20401726902017 @default.
- W2040172690 countsByYear W20401726902018 @default.
- W2040172690 countsByYear W20401726902019 @default.
- W2040172690 countsByYear W20401726902020 @default.
- W2040172690 countsByYear W20401726902021 @default.
- W2040172690 countsByYear W20401726902022 @default.
- W2040172690 crossrefType "journal-article" @default.
- W2040172690 hasAuthorship W2040172690A5053943358 @default.
- W2040172690 hasAuthorship W2040172690A5062271003 @default.
- W2040172690 hasAuthorship W2040172690A5063628247 @default.
- W2040172690 hasAuthorship W2040172690A5075008449 @default.
- W2040172690 hasAuthorship W2040172690A5084031628 @default.
- W2040172690 hasConcept C164027704 @default.
- W2040172690 hasConcept C185592680 @default.
- W2040172690 hasConcept C199343813 @default.
- W2040172690 hasConcept C203014093 @default.
- W2040172690 hasConcept C2776709541 @default.
- W2040172690 hasConcept C2776914184 @default.
- W2040172690 hasConcept C2778690821 @default.
- W2040172690 hasConcept C2780183776 @default.
- W2040172690 hasConcept C2780385504 @default.
- W2040172690 hasConcept C2780758401 @default.
- W2040172690 hasConcept C71924100 @default.
- W2040172690 hasConcept C86803240 @default.
- W2040172690 hasConcept C89423630 @default.
- W2040172690 hasConcept C98274493 @default.
- W2040172690 hasConceptScore W2040172690C164027704 @default.
- W2040172690 hasConceptScore W2040172690C185592680 @default.
- W2040172690 hasConceptScore W2040172690C199343813 @default.
- W2040172690 hasConceptScore W2040172690C203014093 @default.
- W2040172690 hasConceptScore W2040172690C2776709541 @default.
- W2040172690 hasConceptScore W2040172690C2776914184 @default.
- W2040172690 hasConceptScore W2040172690C2778690821 @default.
- W2040172690 hasConceptScore W2040172690C2780183776 @default.
- W2040172690 hasConceptScore W2040172690C2780385504 @default.
- W2040172690 hasConceptScore W2040172690C2780758401 @default.
- W2040172690 hasConceptScore W2040172690C71924100 @default.
- W2040172690 hasConceptScore W2040172690C86803240 @default.
- W2040172690 hasConceptScore W2040172690C89423630 @default.
- W2040172690 hasConceptScore W2040172690C98274493 @default.
- W2040172690 hasFunder F4320332161 @default.