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- W2040187783 abstract "Purpose: This study was performed to evaluate the long-term effect of 0.05% cyclosporine A emulsion (Restasis, Allergan Inc. USA.) on dry eye associated with graft-versus-host disease (GVHD). Methods: Sixteen eyes of 8 patients with severe dry eye associated with GVHD were treated with 0.05% cyclosporine A emulsion twice a day. Tear film parameters were evaluated before treatment and after 1, 3, 6, and 12 months of treatment. Results: One month after treatment, tear break-up time improved from 3.881.78 s to 4.171.90 s (P=0.02). Three months after treatment, symptom score and basal secretion improved from 3.000.38 and 4.441.59 mm to 2.330.52 (P=0.04) and 5.422.50 mm (P=0.04), respectively. Twelve months after treatment, the keratoepitheliopathy score improved from 2.381.31 to 1.130.35 (P=0.02). Conclusions: Use of a 0.05% cyclosporine A emulsion is effective for dry eye associated with GVHD as it helps to increase tear secretion and to relieve symptoms. Treatment with 0.05% cyclosporine A emulsion for longer than 1 year may be necessary to improve keratoepitheliopathy." @default.
- W2040187783 created "2016-06-24" @default.
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- W2040187783 date "2009-01-01" @default.
- W2040187783 modified "2023-09-25" @default.
- W2040187783 title "Long-term Evaluation After Topical Cyclosporine Treatment in Dry Eye Patients With Graft-Versus-Host Disease" @default.
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- W2040187783 doi "https://doi.org/10.3341/jkos.2009.50.1.27" @default.
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