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• W2040204522 endingPage "S28" @default.
• W2040204522 startingPage "S28" @default.
• W2040204522 abstract "The main objective of this study is to detect the early changes in resting-state Papez circuit functional connectivity using the hippocampus as the seed, and to determine the associations between altered functional connectivity (FC) and the episodic memory performance in cognitively intact middle-aged apolipoprotein E4 (APOE4) carriers who are at risk of Alzheimer's disease (AD). Forty-six cognitively intact, middle-aged participants, including 20 APOE4 carriers and 26 age-, sex-, and education-matched noncarriers were studied. The resting-state FC of the hippocampus (HFC) was compared between APOE4 carriers and noncarriers. APOE4 carriers showed significantly decreased FC in brain areas that involve learning and memory functions, including the frontal, cingulate, thalamus and basal ganglia regions. Multiple linear regression analysis showed significant correlations between HFC and the episodic memory performance. Conjunction analysis between neural correlates of memory and altered HFC showed the overlapping regions, especially the subcortical regions such as thalamus, caudate nucleus, and cingulate cortices involved in the Papez circuit. Thus, changes in connectivity in the Papez circuit may be used as an early risk detection for AD." @default.
• W2040204522 created "2016-06-24" @default.
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• W2040204522 date "2014-03-01" @default.
• W2040204522 modified "2023-09-26" @default.
• W2040204522 title "P.1.030 Three week bright-light intervention has dose-related effects on threat-related corticolimbic reactivity and functional coupling" @default.
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• W2040204522 doi "https://doi.org/10.1016/s0924-977x(14)70032-x" @default.
• W2040204522 hasPublicationYear "2014" @default.
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