Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040209910> ?p ?o ?g. }
- W2040209910 endingPage "1256" @default.
- W2040209910 startingPage "1251" @default.
- W2040209910 abstract "The principal nucleus of the bed nucleus of the stria terminalis (BNSTp) is larger in males than in females of several species. We previously demonstrated that in mice lacking the pro-death gene, bax, total BNSTp cell number is increased and sex differences in cell number are eliminated. This suggests that Bax-dependent cell death underlies sexual differentiation of the BNSTp. However, it is not known what cells in the BNSTp are affected by bax deletion. Here we used immunohistochemistry and stereological techniques to quantify phenotypically-identified cells in the BNSTp of adult male and female bax −/− and bax +/+ mice. Sections were thionin-stained, or double-labeled for antigen expressed in neuronal nuclei (NeuN) and glial fibrillary acidic protein (GFAP) to identify mature neurons and astrocytes, respectively; an additional series was labeled for androgen receptor (AR). As previously demonstrated, sex differences in BNSTp area and overall cell number were seen in wild-type mice, but absent in bax −/− animals. In addition, sex differences (favoring males) were present in the number of NeuN+ and AR+ cells in wild-type mice. Bax gene deletion significantly increased the number of NeuN+ and AR+ cells and reduced or eliminated the sex differences in these cell types. The number of astrocytes in the BNSTp was not sexually dimorphic, nor significantly affected by bax gene status, although there was a trend for more GFAP+ cells in bax −/− mice. Overall brain weight was also greater in bax −/− animals compared with controls. We conclude that the sex differences in neuron and AR+ cell number are due at least in part to Bax-mediated cell death. Increased NeuN+ and AR+ cell number in bax −/− mice suggests that supernumerary cells in bax knockouts differentiate similarly to those in wild-type mice, and retain the capacity to respond to androgens." @default.
- W2040209910 created "2016-06-24" @default.
- W2040209910 creator A5025659037 @default.
- W2040209910 creator A5068044369 @default.
- W2040209910 creator A5088504894 @default.
- W2040209910 date "2009-02-01" @default.
- W2040209910 modified "2023-09-26" @default.
- W2040209910 title "Sex differences in NeuN- and androgen receptor–positive cells in the bed nucleus of the stria terminalis are due to Bax-dependent cell death" @default.
- W2040209910 cites W1560820741 @default.
- W2040209910 cites W1671897850 @default.
- W2040209910 cites W1964770396 @default.
- W2040209910 cites W1966354382 @default.
- W2040209910 cites W1968958506 @default.
- W2040209910 cites W1984547206 @default.
- W2040209910 cites W1989347905 @default.
- W2040209910 cites W2000529918 @default.
- W2040209910 cites W2009986139 @default.
- W2040209910 cites W2010498064 @default.
- W2040209910 cites W2026873116 @default.
- W2040209910 cites W2027848195 @default.
- W2040209910 cites W2031326939 @default.
- W2040209910 cites W2032627607 @default.
- W2040209910 cites W2033293623 @default.
- W2040209910 cites W2040603263 @default.
- W2040209910 cites W2043908727 @default.
- W2040209910 cites W2045434155 @default.
- W2040209910 cites W2048026169 @default.
- W2040209910 cites W2050581082 @default.
- W2040209910 cites W2061111210 @default.
- W2040209910 cites W2064131017 @default.
- W2040209910 cites W2070784027 @default.
- W2040209910 cites W2081828196 @default.
- W2040209910 cites W2088584804 @default.
- W2040209910 cites W2102859219 @default.
- W2040209910 cites W2112203969 @default.
- W2040209910 cites W2119627796 @default.
- W2040209910 cites W2124003564 @default.
- W2040209910 cites W2134506701 @default.
- W2040209910 cites W2135725455 @default.
- W2040209910 cites W2144727302 @default.
- W2040209910 cites W2150771326 @default.
- W2040209910 cites W2153783390 @default.
- W2040209910 cites W2169926615 @default.
- W2040209910 cites W4291064879 @default.
- W2040209910 doi "https://doi.org/10.1016/j.neuroscience.2008.11.020" @default.
- W2040209910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2646815" @default.
- W2040209910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19059313" @default.
- W2040209910 hasPublicationYear "2009" @default.
- W2040209910 type Work @default.
- W2040209910 sameAs 2040209910 @default.
- W2040209910 citedByCount "21" @default.
- W2040209910 countsByYear W20402099102012 @default.
- W2040209910 countsByYear W20402099102013 @default.
- W2040209910 countsByYear W20402099102015 @default.
- W2040209910 countsByYear W20402099102016 @default.
- W2040209910 countsByYear W20402099102017 @default.
- W2040209910 countsByYear W20402099102020 @default.
- W2040209910 crossrefType "journal-article" @default.
- W2040209910 hasAuthorship W2040209910A5025659037 @default.
- W2040209910 hasAuthorship W2040209910A5068044369 @default.
- W2040209910 hasAuthorship W2040209910A5088504894 @default.
- W2040209910 hasBestOaLocation W20402099102 @default.
- W2040209910 hasConcept C121608353 @default.
- W2040209910 hasConcept C126322002 @default.
- W2040209910 hasConcept C134018914 @default.
- W2040209910 hasConcept C153911025 @default.
- W2040209910 hasConcept C170493617 @default.
- W2040209910 hasConcept C190283241 @default.
- W2040209910 hasConcept C203014093 @default.
- W2040209910 hasConcept C204232928 @default.
- W2040209910 hasConcept C2778652331 @default.
- W2040209910 hasConcept C2780192828 @default.
- W2040209910 hasConcept C2780495277 @default.
- W2040209910 hasConcept C2780723820 @default.
- W2040209910 hasConcept C2781100881 @default.
- W2040209910 hasConcept C31573885 @default.
- W2040209910 hasConcept C54355233 @default.
- W2040209910 hasConcept C61367390 @default.
- W2040209910 hasConcept C71924100 @default.
- W2040209910 hasConcept C86803240 @default.
- W2040209910 hasConcept C95444343 @default.
- W2040209910 hasConceptScore W2040209910C121608353 @default.
- W2040209910 hasConceptScore W2040209910C126322002 @default.
- W2040209910 hasConceptScore W2040209910C134018914 @default.
- W2040209910 hasConceptScore W2040209910C153911025 @default.
- W2040209910 hasConceptScore W2040209910C170493617 @default.
- W2040209910 hasConceptScore W2040209910C190283241 @default.
- W2040209910 hasConceptScore W2040209910C203014093 @default.
- W2040209910 hasConceptScore W2040209910C204232928 @default.
- W2040209910 hasConceptScore W2040209910C2778652331 @default.
- W2040209910 hasConceptScore W2040209910C2780192828 @default.
- W2040209910 hasConceptScore W2040209910C2780495277 @default.
- W2040209910 hasConceptScore W2040209910C2780723820 @default.
- W2040209910 hasConceptScore W2040209910C2781100881 @default.
- W2040209910 hasConceptScore W2040209910C31573885 @default.
- W2040209910 hasConceptScore W2040209910C54355233 @default.
- W2040209910 hasConceptScore W2040209910C61367390 @default.
- W2040209910 hasConceptScore W2040209910C71924100 @default.