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- W2040213937 abstract "A recently developed nonparametric method is a generalization of the transmission disequilibrium test across all alleles of a locus. This approach has been applied to Problem 2 of GAW10 and has been extended to explore the combined contribution of neighboring loci for chromosomes 1, 5, and 8. When applied to the chromosome 5 data of the first replicate of the nuclear pedigrees from Problem 2 of GAW10, the data show that four of the 25 loci obtain a probability less than 0.05. However, when combined models composed of each potentially significant marker (p < 0.05) and its nearest neighbors are considered, the combined contributions of G14 and G15 are the most significant (p = 0.007). Consequently, the region near G14 and G15 is identified as the best candidate region in chromosome 5 for linkage to the common disease." @default.
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- W2040213937 date "1997-01-01" @default.
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- W2040213937 title "Logistic transmission modeling for the simulated data of GAW10 problem 2" @default.
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- W2040213937 doi "https://doi.org/10.1002/(sici)1098-2272(1997)14:6<857::aid-gepi49>3.0.co;2-m" @default.
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