Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040217194> ?p ?o ?g. }
- W2040217194 endingPage "332" @default.
- W2040217194 startingPage "328" @default.
- W2040217194 abstract "The molecular mechanisms for regulating water balance in many tissues are unknown. Like the kidney, the eye contains multiple water channel proteins (aquaporins) that transport water through membranes, including two (AQP1 and AQP4) in the ciliary body, the site of aqueous humor production. Previous results from our laboratory demonstrated that water channel activity of AQP1 was significantly increased by protein kinase A (PKA) activators such as cyclic-AMP (cAMP) and forskolin. The purpose of this study is to determine whether PKA-dependent protein phosphorylation is involved in the regulation of water channel activity of AQP1. Results presented here suggest that catalytic subunit of protein kinase A significantly increased the amount of phosphorylated AQP1 protein. In addition, these results indicated that cAMP-responsive redistribution of AQP1 may be regulated by phosphorylation of AQP1. Moreover, they provide new insights on the molecular mechanisms for regulating water balance in several tissues involving rapid water transport such as ciliary epithelium. In addition, they suggest important potential roles for AQP1 in several clinical disorders involving rapid water transport such as glaucoma." @default.
- W2040217194 created "2016-06-24" @default.
- W2040217194 creator A5014033508 @default.
- W2040217194 creator A5048745973 @default.
- W2040217194 date "2000-06-01" @default.
- W2040217194 modified "2023-10-12" @default.
- W2040217194 title "Protein Kinase A-Dependent Phosphorylation of Aquaporin-1" @default.
- W2040217194 cites W136300496 @default.
- W2040217194 cites W1495656315 @default.
- W2040217194 cites W1504478980 @default.
- W2040217194 cites W1850214287 @default.
- W2040217194 cites W1936238841 @default.
- W2040217194 cites W1970305997 @default.
- W2040217194 cites W1971226411 @default.
- W2040217194 cites W1972028691 @default.
- W2040217194 cites W1972946535 @default.
- W2040217194 cites W1975485655 @default.
- W2040217194 cites W1979341445 @default.
- W2040217194 cites W1984284559 @default.
- W2040217194 cites W2006986579 @default.
- W2040217194 cites W2018274667 @default.
- W2040217194 cites W2018779154 @default.
- W2040217194 cites W2020099135 @default.
- W2040217194 cites W2020839799 @default.
- W2040217194 cites W2038298695 @default.
- W2040217194 cites W2042577267 @default.
- W2040217194 cites W2055622790 @default.
- W2040217194 cites W2079126167 @default.
- W2040217194 cites W2081687341 @default.
- W2040217194 cites W2082414348 @default.
- W2040217194 cites W2085238893 @default.
- W2040217194 cites W2093038960 @default.
- W2040217194 cites W2098730572 @default.
- W2040217194 cites W2098754254 @default.
- W2040217194 cites W2105859090 @default.
- W2040217194 cites W2112677669 @default.
- W2040217194 cites W2121594383 @default.
- W2040217194 cites W2132452670 @default.
- W2040217194 cites W2153210703 @default.
- W2040217194 cites W2154312242 @default.
- W2040217194 cites W2168056652 @default.
- W2040217194 cites W2334838478 @default.
- W2040217194 cites W4249492942 @default.
- W2040217194 cites W54418235 @default.
- W2040217194 doi "https://doi.org/10.1006/bbrc.2000.2944" @default.
- W2040217194 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10873606" @default.
- W2040217194 hasPublicationYear "2000" @default.
- W2040217194 type Work @default.
- W2040217194 sameAs 2040217194 @default.
- W2040217194 citedByCount "62" @default.
- W2040217194 countsByYear W20402171942012 @default.
- W2040217194 countsByYear W20402171942014 @default.
- W2040217194 countsByYear W20402171942015 @default.
- W2040217194 countsByYear W20402171942016 @default.
- W2040217194 countsByYear W20402171942017 @default.
- W2040217194 countsByYear W20402171942018 @default.
- W2040217194 countsByYear W20402171942019 @default.
- W2040217194 countsByYear W20402171942020 @default.
- W2040217194 countsByYear W20402171942021 @default.
- W2040217194 countsByYear W20402171942022 @default.
- W2040217194 countsByYear W20402171942023 @default.
- W2040217194 crossrefType "journal-article" @default.
- W2040217194 hasAuthorship W2040217194A5014033508 @default.
- W2040217194 hasAuthorship W2040217194A5048745973 @default.
- W2040217194 hasConcept C104292427 @default.
- W2040217194 hasConcept C104317684 @default.
- W2040217194 hasConcept C11960822 @default.
- W2040217194 hasConcept C12554922 @default.
- W2040217194 hasConcept C127413603 @default.
- W2040217194 hasConcept C140737988 @default.
- W2040217194 hasConcept C154280991 @default.
- W2040217194 hasConcept C177586851 @default.
- W2040217194 hasConcept C184235292 @default.
- W2040217194 hasConcept C185592680 @default.
- W2040217194 hasConcept C201289731 @default.
- W2040217194 hasConcept C202751555 @default.
- W2040217194 hasConcept C2775845273 @default.
- W2040217194 hasConcept C2779276759 @default.
- W2040217194 hasConcept C2988574769 @default.
- W2040217194 hasConcept C2992163139 @default.
- W2040217194 hasConcept C55493867 @default.
- W2040217194 hasConcept C78519656 @default.
- W2040217194 hasConcept C86803240 @default.
- W2040217194 hasConcept C87325107 @default.
- W2040217194 hasConcept C87717796 @default.
- W2040217194 hasConcept C95444343 @default.
- W2040217194 hasConcept C97029542 @default.
- W2040217194 hasConceptScore W2040217194C104292427 @default.
- W2040217194 hasConceptScore W2040217194C104317684 @default.
- W2040217194 hasConceptScore W2040217194C11960822 @default.
- W2040217194 hasConceptScore W2040217194C12554922 @default.
- W2040217194 hasConceptScore W2040217194C127413603 @default.
- W2040217194 hasConceptScore W2040217194C140737988 @default.
- W2040217194 hasConceptScore W2040217194C154280991 @default.
- W2040217194 hasConceptScore W2040217194C177586851 @default.
- W2040217194 hasConceptScore W2040217194C184235292 @default.
- W2040217194 hasConceptScore W2040217194C185592680 @default.
- W2040217194 hasConceptScore W2040217194C201289731 @default.