Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040217489> ?p ?o ?g. }
- W2040217489 abstract "Abstract Morphologic and biochemical changes occur during red cell storage prior to product expiry, and these changes may hinder erythrocyte viability and function following transfusion. Despite a relatively large body of literature detailing the metabolic and structural deterioration that occurs during red cell storage, evidence for a significant detrimental clinical effect related to the transfusion of older blood is relatively less conclusive, limited primarily to observations in retrospective studies. Nonetheless, the implication that the transfusion of old, but not outdated blood may have negative clinical consequences demands attention. In this report, the current understanding of the biochemical and structural changes that occur during storage, known collectively as the storage lesion, is described, and the clinical evidence concerning the detrimental consequences associated with the transfusion of relatively older red cells is critically reviewed. Although the growing body of literature demonstrating the deleterious effects of relatively old blood is compelling, it is notable that all of these reports have been retrospective, and most of these studies have evaluated patients who received a mixture of red cell units of varying storage age. Until prospective studies have been completed and produce confirmative results, it would be premature to recommend any modification of current transfusion practice regarding storage age. In 1917, Frances Payton Rous and J.R. Turner identified that a citrate-glucose solution allowed for the preservation of a whole blood unit for up to five days, thus facilitating the formative practice of blood banking[1]. Later, Loutit and Mollison of Great Britain developed the first anticoagulant of the modern era, known as acid-citrate-dextrose (ACD)[1]. ACD extended the shelf life of refrigerated blood to 21 days, and ACD remained in wide spread usage until the 1960s, when it was replaced by citrate-phosphate-dextrose (CPD) and citrate-phosphate-dextrose-adenine (CPDA) solutions that increased shelf life to 35 days and 42 days respectively. More recently, additive solutions containing saline, adenine, and dextrose have been developed to augment red cell survival following transfusion, although without any direct increase in storage duration[1, 2]. It is now well appreciated, however, that a number of morphologic and biochemical changes occur during red cell storage prior to product expiry, and these changes may hinder erythrocyte viability and function following transfusion. Despite a relatively large body of literature detailing the metabolic and structural deterioration that occurs during red cell storage, evidence for a significant detrimental clinical effect related to the transfusion of older blood is relatively less conclusive, limited primarily to observations in retrospective studies. Nonetheless, the implication that the transfusion of old, but not outdated blood may have negative clinical consequences demands attention. The purpose of this report is to describe the current understanding of the biochemical and structural changes that occur during storage, known collectively as the storage lesion, and to critically review the clinical evidence concerning the detrimental consequences associated with the transfusion of relatively older red cells." @default.
- W2040217489 created "2016-06-24" @default.
- W2040217489 creator A5009828067 @default.
- W2040217489 creator A5034214909 @default.
- W2040217489 creator A5063498672 @default.
- W2040217489 date "2009-08-13" @default.
- W2040217489 modified "2023-09-25" @default.
- W2040217489 title "Blood transfusion in the critically ill: does storage age matter?" @default.
- W2040217489 cites W1966434594 @default.
- W2040217489 cites W1968507156 @default.
- W2040217489 cites W1982357371 @default.
- W2040217489 cites W1989176457 @default.
- W2040217489 cites W1993563216 @default.
- W2040217489 cites W2006569302 @default.
- W2040217489 cites W2006587953 @default.
- W2040217489 cites W2030824516 @default.
- W2040217489 cites W2037099335 @default.
- W2040217489 cites W2037137255 @default.
- W2040217489 cites W2041534048 @default.
- W2040217489 cites W2051755430 @default.
- W2040217489 cites W2053478780 @default.
- W2040217489 cites W2053549173 @default.
- W2040217489 cites W2055317281 @default.
- W2040217489 cites W2057703018 @default.
- W2040217489 cites W2069700927 @default.
- W2040217489 cites W2077637580 @default.
- W2040217489 cites W2081528628 @default.
- W2040217489 cites W2085380448 @default.
- W2040217489 cites W2091539702 @default.
- W2040217489 cites W2094815596 @default.
- W2040217489 cites W2107921622 @default.
- W2040217489 cites W2116957157 @default.
- W2040217489 cites W2136322639 @default.
- W2040217489 cites W2139657701 @default.
- W2040217489 cites W2151788599 @default.
- W2040217489 cites W2159161470 @default.
- W2040217489 cites W2161860918 @default.
- W2040217489 cites W2413244886 @default.
- W2040217489 doi "https://doi.org/10.1186/1757-7241-17-35" @default.
- W2040217489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2733299" @default.
- W2040217489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19678943" @default.
- W2040217489 hasPublicationYear "2009" @default.
- W2040217489 type Work @default.
- W2040217489 sameAs 2040217489 @default.
- W2040217489 citedByCount "62" @default.
- W2040217489 countsByYear W20402174892012 @default.
- W2040217489 countsByYear W20402174892013 @default.
- W2040217489 countsByYear W20402174892014 @default.
- W2040217489 countsByYear W20402174892015 @default.
- W2040217489 countsByYear W20402174892016 @default.
- W2040217489 countsByYear W20402174892017 @default.
- W2040217489 countsByYear W20402174892018 @default.
- W2040217489 countsByYear W20402174892019 @default.
- W2040217489 countsByYear W20402174892020 @default.
- W2040217489 countsByYear W20402174892021 @default.
- W2040217489 countsByYear W20402174892022 @default.
- W2040217489 crossrefType "journal-article" @default.
- W2040217489 hasAuthorship W2040217489A5009828067 @default.
- W2040217489 hasAuthorship W2040217489A5034214909 @default.
- W2040217489 hasAuthorship W2040217489A5063498672 @default.
- W2040217489 hasBestOaLocation W20402174891 @default.
- W2040217489 hasConcept C141071460 @default.
- W2040217489 hasConcept C177713679 @default.
- W2040217489 hasConcept C203014093 @default.
- W2040217489 hasConcept C2776557347 @default.
- W2040217489 hasConcept C2777396833 @default.
- W2040217489 hasConcept C2780014101 @default.
- W2040217489 hasConcept C42407357 @default.
- W2040217489 hasConcept C71924100 @default.
- W2040217489 hasConcept C79592252 @default.
- W2040217489 hasConceptScore W2040217489C141071460 @default.
- W2040217489 hasConceptScore W2040217489C177713679 @default.
- W2040217489 hasConceptScore W2040217489C203014093 @default.
- W2040217489 hasConceptScore W2040217489C2776557347 @default.
- W2040217489 hasConceptScore W2040217489C2777396833 @default.
- W2040217489 hasConceptScore W2040217489C2780014101 @default.
- W2040217489 hasConceptScore W2040217489C42407357 @default.
- W2040217489 hasConceptScore W2040217489C71924100 @default.
- W2040217489 hasConceptScore W2040217489C79592252 @default.
- W2040217489 hasIssue "1" @default.
- W2040217489 hasLocation W20402174891 @default.
- W2040217489 hasLocation W20402174892 @default.
- W2040217489 hasLocation W20402174893 @default.
- W2040217489 hasLocation W20402174894 @default.
- W2040217489 hasOpenAccess W2040217489 @default.
- W2040217489 hasPrimaryLocation W20402174891 @default.
- W2040217489 hasRelatedWork W1566760294 @default.
- W2040217489 hasRelatedWork W2171828594 @default.
- W2040217489 hasRelatedWork W2472699217 @default.
- W2040217489 hasRelatedWork W2736277576 @default.
- W2040217489 hasRelatedWork W2802036117 @default.
- W2040217489 hasRelatedWork W2928755247 @default.
- W2040217489 hasRelatedWork W2981695145 @default.
- W2040217489 hasRelatedWork W4243571962 @default.
- W2040217489 hasRelatedWork W4295365236 @default.
- W2040217489 hasRelatedWork W4317433590 @default.
- W2040217489 hasVolume "17" @default.
- W2040217489 isParatext "false" @default.
- W2040217489 isRetracted "false" @default.
- W2040217489 magId "2040217489" @default.