FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040221651> ?p ?o ?g. }

• W2040221651 endingPage "808" @default.
• W2040221651 startingPage "795" @default.
• W2040221651 abstract "Progering® is the only intravaginal ring intended for contraception therapies during lactation. It is made of silicone and releases progesterone through the vaginal walls. However, some drawbacks have been reported in the use of silicone. Therefore, ethylene vinyl acetate copolymer (EVA) was tested in order to replace it. EVA rings were produced by a hot-melt extrusion procedure. Swelling and degradation assays of these matrices were conducted in different mixtures of ethanol/water. Solubility and partition coefficient of progesterone were measured, together with the initial hormone load and characteristic dimensions. A mathematical model was used to design an EVA ring that releases the hormone at specific rate. An EVA ring releasing progesterone in vitro at about 12.05 ± 8.91 mg day−1 was successfully designed. This rate of release is similar to that observed for Progering®. In addition, it was observed that as the initial hormone load or ring dimension increases, the rate of release also increases. Also, the device lifetime was extended with a rise in the initial amount of hormone load. EVA rings could be designed to release progesterone in vitro at a rate of 12.05 ± 8.91 mg day−1. This ring would be used in contraception therapies during lactation. The use of EVA in this field could have initially several advantages: less initial and residual hormone content in rings, no need for additional steps of curing or crosslinking, less manufacturing time and costs, and the possibility to recycle the used rings." @default.
• W2040221651 created "2016-06-24" @default.
• W2040221651 creator A5055343187 @default.
• W2040221651 creator A5067739802 @default.
• W2040221651 creator A5070868903 @default.
• W2040221651 date "2013-10-18" @default.
• W2040221651 modified "2023-10-16" @default.
• W2040221651 title "The Optimization of an Intravaginal Ring Releasing Progesterone Using a Mathematical Model" @default.
• W2040221651 cites W128476148 @default.
• W2040221651 cites W1520349470 @default.
• W2040221651 cites W1967562318 @default.
• W2040221651 cites W1968540870 @default.
• W2040221651 cites W1971629639 @default.
• W2040221651 cites W1971811535 @default.
• W2040221651 cites W1973111270 @default.
• W2040221651 cites W1976275542 @default.
• W2040221651 cites W1977178862 @default.
• W2040221651 cites W1977922405 @default.
• W2040221651 cites W1982313253 @default.
• W2040221651 cites W1988146607 @default.
• W2040221651 cites W1989954877 @default.
• W2040221651 cites W1995698427 @default.
• W2040221651 cites W1999128252 @default.
• W2040221651 cites W1999501080 @default.
• W2040221651 cites W2001211063 @default.
• W2040221651 cites W2004123015 @default.
• W2040221651 cites W2012286455 @default.
• W2040221651 cites W2023468792 @default.
• W2040221651 cites W2025986796 @default.
• W2040221651 cites W2028615008 @default.
• W2040221651 cites W2031911044 @default.
• W2040221651 cites W2031929091 @default.
• W2040221651 cites W2032835177 @default.
• W2040221651 cites W2034342251 @default.
• W2040221651 cites W2044853520 @default.
• W2040221651 cites W2049127485 @default.
• W2040221651 cites W2051264062 @default.
• W2040221651 cites W2056735484 @default.
• W2040221651 cites W2060008979 @default.
• W2040221651 cites W2062212037 @default.
• W2040221651 cites W2063227735 @default.
• W2040221651 cites W2068776200 @default.
• W2040221651 cites W2071901173 @default.
• W2040221651 cites W2072494411 @default.
• W2040221651 cites W2074759255 @default.
• W2040221651 cites W2075244458 @default.
• W2040221651 cites W2075882529 @default.
• W2040221651 cites W2079781355 @default.
• W2040221651 cites W2083101998 @default.
• W2040221651 cites W2083844680 @default.
• W2040221651 cites W2087751719 @default.
• W2040221651 cites W2089678069 @default.
• W2040221651 cites W2092657771 @default.
• W2040221651 cites W2093895231 @default.
• W2040221651 cites W2104939725 @default.
• W2040221651 cites W2107252468 @default.
• W2040221651 cites W2115439624 @default.
• W2040221651 cites W2120559553 @default.
• W2040221651 cites W2131404154 @default.
• W2040221651 cites W2134174370 @default.
• W2040221651 cites W2142408999 @default.
• W2040221651 cites W2147469536 @default.
• W2040221651 cites W2148505598 @default.
• W2040221651 cites W2150478750 @default.
• W2040221651 cites W2151996036 @default.
• W2040221651 cites W2154452493 @default.
• W2040221651 cites W2158600879 @default.
• W2040221651 cites W2243920888 @default.
• W2040221651 cites W49651065 @default.
• W2040221651 cites W2074498875 @default.
• W2040221651 cites W2083944945 @default.
• W2040221651 doi "https://doi.org/10.1007/s11095-013-1201-6" @default.
• W2040221651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24135933" @default.
• W2040221651 hasPublicationYear "2013" @default.
• W2040221651 type Work @default.
• W2040221651 sameAs 2040221651 @default.
• W2040221651 citedByCount "27" @default.
• W2040221651 countsByYear W20402216512014 @default.
• W2040221651 countsByYear W20402216512015 @default.
• W2040221651 countsByYear W20402216512016 @default.
• W2040221651 countsByYear W20402216512017 @default.
• W2040221651 countsByYear W20402216512018 @default.
• W2040221651 countsByYear W20402216512019 @default.
• W2040221651 countsByYear W20402216512020 @default.
• W2040221651 countsByYear W20402216512021 @default.
• W2040221651 countsByYear W20402216512023 @default.
• W2040221651 crossrefType "journal-article" @default.
• W2040221651 hasAuthorship W2040221651A5055343187 @default.
• W2040221651 hasAuthorship W2040221651A5067739802 @default.
• W2040221651 hasAuthorship W2040221651A5070868903 @default.
• W2040221651 hasBestOaLocation W20402216512 @default.
• W2040221651 hasConcept C15920480 @default.
• W2040221651 hasConcept C178790620 @default.
• W2040221651 hasConcept C185592680 @default.
• W2040221651 hasConcept C188027245 @default.
• W2040221651 hasConcept C192562407 @default.
• W2040221651 hasConcept C2779076696 @default.
• W2040221651 hasConcept C2779755712 @default.

• next