Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040223721> ?p ?o ?g. }
- W2040223721 endingPage "e29" @default.
- W2040223721 startingPage "e29" @default.
- W2040223721 abstract "Recent findings on the role of transforming growth factor (TGF)-β/Smad3 signaling in the pathogenesis of obesity and type 2 diabetes have underscored its importance in metabolism and adiposity. Indeed, elevated TGF-β has been previously reported in human adipose tissue during morbid obesity and diabetic neuropathy. In this review, we discuss the pleiotropic effects of TGF-β/Smad3 signaling on metabolism and energy homeostasis, all of which has an important part in the etiology and progression of obesity-linked diabetes; these include adipocyte differentiation, white to brown fat phenotypic transition, glucose and lipid metabolism, pancreatic function, insulin signaling, adipocytokine secretion, inflammation and reactive oxygen species production. We summarize the recent in vivo findings on the role of TGF-β/Smad3 signaling in metabolism based on the studies using Smad3(-/-) mice. Based on the presence of a dual regulatory effect of Smad3 on peroxisome proliferator-activated receptor (PPAR)β/δ and PPARγ2 promoters, we propose a unifying mechanism by which this signaling pathway contributes to obesity and its associated diabetes. We also discuss how the inhibition of this signaling pathway has been implicated in the amelioration of many facets of metabolic syndromes, thereby offering novel therapeutic avenues for these metabolic conditions." @default.
- W2040223721 created "2016-06-24" @default.
- W2040223721 creator A5004811732 @default.
- W2040223721 creator A5009852025 @default.
- W2040223721 creator A5059974201 @default.
- W2040223721 creator A5062669488 @default.
- W2040223721 date "2012-03-05" @default.
- W2040223721 modified "2023-09-26" @default.
- W2040223721 title "Getting ‘Smad’ about obesity and diabetes" @default.
- W2040223721 cites W1963619735 @default.
- W2040223721 cites W1965621923 @default.
- W2040223721 cites W1966270083 @default.
- W2040223721 cites W1967964480 @default.
- W2040223721 cites W1969384498 @default.
- W2040223721 cites W1972248992 @default.
- W2040223721 cites W1974599416 @default.
- W2040223721 cites W1977069725 @default.
- W2040223721 cites W1979286266 @default.
- W2040223721 cites W1981034583 @default.
- W2040223721 cites W1985325808 @default.
- W2040223721 cites W1989244177 @default.
- W2040223721 cites W1992105713 @default.
- W2040223721 cites W1992326632 @default.
- W2040223721 cites W1993959456 @default.
- W2040223721 cites W1997304834 @default.
- W2040223721 cites W1997894574 @default.
- W2040223721 cites W1999445997 @default.
- W2040223721 cites W2005720719 @default.
- W2040223721 cites W2007489122 @default.
- W2040223721 cites W2007634515 @default.
- W2040223721 cites W2008777641 @default.
- W2040223721 cites W2009629707 @default.
- W2040223721 cites W2010509924 @default.
- W2040223721 cites W2011246715 @default.
- W2040223721 cites W2011255130 @default.
- W2040223721 cites W2012067669 @default.
- W2040223721 cites W2012834939 @default.
- W2040223721 cites W2014702327 @default.
- W2040223721 cites W2014901805 @default.
- W2040223721 cites W2017292651 @default.
- W2040223721 cites W2017783641 @default.
- W2040223721 cites W2018803560 @default.
- W2040223721 cites W2019788712 @default.
- W2040223721 cites W2020267609 @default.
- W2040223721 cites W2021226726 @default.
- W2040223721 cites W2026428548 @default.
- W2040223721 cites W2027302080 @default.
- W2040223721 cites W2034618205 @default.
- W2040223721 cites W2035458523 @default.
- W2040223721 cites W2038018821 @default.
- W2040223721 cites W2038064796 @default.
- W2040223721 cites W2038408489 @default.
- W2040223721 cites W2038459771 @default.
- W2040223721 cites W2038961236 @default.
- W2040223721 cites W2039011321 @default.
- W2040223721 cites W2040671595 @default.
- W2040223721 cites W2044798581 @default.
- W2040223721 cites W2047102823 @default.
- W2040223721 cites W2048424792 @default.
- W2040223721 cites W2051372978 @default.
- W2040223721 cites W2051415594 @default.
- W2040223721 cites W2057249117 @default.
- W2040223721 cites W2061309116 @default.
- W2040223721 cites W2064112171 @default.
- W2040223721 cites W2069911905 @default.
- W2040223721 cites W2076310317 @default.
- W2040223721 cites W2079189474 @default.
- W2040223721 cites W2080353970 @default.
- W2040223721 cites W2080424087 @default.
- W2040223721 cites W2082224082 @default.
- W2040223721 cites W2088026447 @default.
- W2040223721 cites W2088971991 @default.
- W2040223721 cites W2089235913 @default.
- W2040223721 cites W2091087465 @default.
- W2040223721 cites W2091272291 @default.
- W2040223721 cites W2092136583 @default.
- W2040223721 cites W2095562829 @default.
- W2040223721 cites W2096842458 @default.
- W2040223721 cites W2098554891 @default.
- W2040223721 cites W2100165518 @default.
- W2040223721 cites W2104437296 @default.
- W2040223721 cites W2104640556 @default.
- W2040223721 cites W2104827888 @default.
- W2040223721 cites W2105767196 @default.
- W2040223721 cites W2108709856 @default.
- W2040223721 cites W2109053696 @default.
- W2040223721 cites W2114111268 @default.
- W2040223721 cites W2115556861 @default.
- W2040223721 cites W2115937740 @default.
- W2040223721 cites W2116613369 @default.
- W2040223721 cites W2121264929 @default.
- W2040223721 cites W2123820248 @default.
- W2040223721 cites W2124821727 @default.
- W2040223721 cites W2126352920 @default.
- W2040223721 cites W2126654945 @default.
- W2040223721 cites W2127555681 @default.
- W2040223721 cites W2129063289 @default.
- W2040223721 cites W2129316761 @default.