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- W2040226341 abstract "Soluble CD83 (sCD83), a potent immunosuppressive agent, circulates at elevated levels in some chronic lymphocytic leukemia (CLL) patients. We report that CLL patients with elevated plasma sCD83 levels had significantly shorter (P = 0.038) treatment free survival. Culture of CLL cells with solid phase CD83 mAb + IL-4 significantly increases sCD83 release (23–117-fold, P = 0.013) and ligation of normal donor PBMC with solid phase CD83 mAb alone induces similar significant increases in sCD83 release (P = 0.003). RT-PCR analysis detected the presence of a transcript for sCD83 in 2/3 CLL samples. These results suggest sCD83 release may play a regulatory role in CLL progression." @default.
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- W2040226341 date "2009-08-01" @default.
- W2040226341 modified "2023-09-25" @default.
- W2040226341 title "Release and clinical significance of soluble CD83 in chronic lymphocytic leukemia" @default.
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- W2040226341 doi "https://doi.org/10.1016/j.leukres.2009.01.001" @default.
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