FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040227938> ?p ?o ?g. }

• W2040227938 endingPage "24" @default.
• W2040227938 startingPage "17" @default.
• W2040227938 abstract "Advancing age is associated with downregulation of fibrinolysis in normal subjects. This is reflected by high concentrations of plasminogen activator inhibitor-1 (PAI-1) in the blood, which has been implicated in the increasing cardiovascular morbidity and mortality with age. We sought to delineate the relation of PAI-1 to several factors, including age, gender, and ethnicity in patients with type 2 diabetes mellitus (DM) and stable coronary artery disease enrolled in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial. A total of 2,321 patients with DM and stable coronary artery disease in the BARI 2D trial were grouped by age (<50, 50 to 59, 60 to 69, and > or =70 years). Tissue-type plasminogen activator antigen, PAI-1 antigen and activity, fibrinogen, and D-dimer were quantified at baseline. The PAI-1 antigen (p <0.001) and its activity (p <0.001) and their ratios to tissue-type plasminogen activator (p <0.001) were all paradoxically lower with advancing age. In contrast, D-dimer (p <0.0001) was elevated. The fibrinogen level was greatest in the oldest age group (p = 0.01). The level of tissue-type plasminogen activator antigen did not vary with age. These age-related differences were observed primarily in men and non-Hispanic white and Asian/other participants. In conclusion, PAI-1 is inversely related to age in patients with DM and stable coronary artery disease and is associated with elevation of D-dimer, reflecting augmented fibrinolysis. The unexpected profibrinolytic state seen with advancing age and DM might reflect a protective phenomenon resulting from enhanced survival of some older patients with DM that endowed the older patients with longevity sufficient to enable them to participate in the BARI 2D trial. Targeting the factors that led to the downregulation of PAI-1 in older patients with type 2 DM might offer an attractive strategy for reducing cardiovascular risk." @default.
• W2040227938 created "2016-06-24" @default.
• W2040227938 creator A5035615314 @default.
• W2040227938 creator A5070819007 @default.
• W2040227938 creator A5089724515 @default.
• W2040227938 date "2010-01-01" @default.
• W2040227938 modified "2023-10-16" @default.
• W2040227938 title "Comparison of Plasminogen Activator Inhibitor-1, Tissue Type Plasminogen Activator Antigen, Fibrinogen, and D-Dimer Levels in Various Age Decades in Patients With Type 2 Diabetes Mellitus and Stable Coronary Artery Disease (from the BARI 2D Trial)" @default.
• W2040227938 cites W1966424372 @default.
• W2040227938 cites W1967778704 @default.
• W2040227938 cites W1975161958 @default.
• W2040227938 cites W1976057876 @default.
• W2040227938 cites W1983854928 @default.
• W2040227938 cites W2001668240 @default.
• W2040227938 cites W2003145038 @default.
• W2040227938 cites W2009371858 @default.
• W2040227938 cites W2013077255 @default.
• W2040227938 cites W2021624187 @default.
• W2040227938 cites W2022705938 @default.
• W2040227938 cites W2034413738 @default.
• W2040227938 cites W2034888646 @default.
• W2040227938 cites W2039831544 @default.
• W2040227938 cites W2040808476 @default.
• W2040227938 cites W2062403855 @default.
• W2040227938 cites W2063875445 @default.
• W2040227938 cites W2076998571 @default.
• W2040227938 cites W2081634539 @default.
• W2040227938 cites W2093550819 @default.
• W2040227938 cites W2102605421 @default.
• W2040227938 cites W2121928790 @default.
• W2040227938 cites W2156213523 @default.
• W2040227938 cites W2287328722 @default.
• W2040227938 doi "https://doi.org/10.1016/j.amjcard.2009.08.643" @default.
• W2040227938 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2814593" @default.
• W2040227938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20102884" @default.
• W2040227938 hasPublicationYear "2010" @default.
• W2040227938 type Work @default.
• W2040227938 sameAs 2040227938 @default.
• W2040227938 citedByCount "34" @default.
• W2040227938 countsByYear W20402279382012 @default.
• W2040227938 countsByYear W20402279382013 @default.
• W2040227938 countsByYear W20402279382014 @default.
• W2040227938 countsByYear W20402279382015 @default.
• W2040227938 countsByYear W20402279382016 @default.
• W2040227938 countsByYear W20402279382017 @default.
• W2040227938 countsByYear W20402279382018 @default.
• W2040227938 countsByYear W20402279382019 @default.
• W2040227938 countsByYear W20402279382020 @default.
• W2040227938 countsByYear W20402279382021 @default.
• W2040227938 countsByYear W20402279382022 @default.
• W2040227938 crossrefType "journal-article" @default.
• W2040227938 hasAuthorship W2040227938A5035615314 @default.
• W2040227938 hasAuthorship W2040227938A5070819007 @default.
• W2040227938 hasAuthorship W2040227938A5089724515 @default.
• W2040227938 hasBestOaLocation W20402279382 @default.
• W2040227938 hasConcept C126322002 @default.
• W2040227938 hasConcept C134018914 @default.
• W2040227938 hasConcept C164705383 @default.
• W2040227938 hasConcept C2776572282 @default.
• W2040227938 hasConcept C2776825266 @default.
• W2040227938 hasConcept C2778213512 @default.
• W2040227938 hasConcept C2778589496 @default.
• W2040227938 hasConcept C2779036427 @default.
• W2040227938 hasConcept C2779679481 @default.
• W2040227938 hasConcept C2780675426 @default.
• W2040227938 hasConcept C2909373784 @default.
• W2040227938 hasConcept C555293320 @default.
• W2040227938 hasConcept C71924100 @default.
• W2040227938 hasConcept C90924648 @default.
• W2040227938 hasConceptScore W2040227938C126322002 @default.
• W2040227938 hasConceptScore W2040227938C134018914 @default.
• W2040227938 hasConceptScore W2040227938C164705383 @default.
• W2040227938 hasConceptScore W2040227938C2776572282 @default.
• W2040227938 hasConceptScore W2040227938C2776825266 @default.
• W2040227938 hasConceptScore W2040227938C2778213512 @default.
• W2040227938 hasConceptScore W2040227938C2778589496 @default.
• W2040227938 hasConceptScore W2040227938C2779036427 @default.
• W2040227938 hasConceptScore W2040227938C2779679481 @default.
• W2040227938 hasConceptScore W2040227938C2780675426 @default.
• W2040227938 hasConceptScore W2040227938C2909373784 @default.
• W2040227938 hasConceptScore W2040227938C555293320 @default.
• W2040227938 hasConceptScore W2040227938C71924100 @default.
• W2040227938 hasConceptScore W2040227938C90924648 @default.
• W2040227938 hasFunder F4320323469 @default.
• W2040227938 hasFunder F4320332161 @default.
• W2040227938 hasFunder F4320337338 @default.
• W2040227938 hasFunder F4320337357 @default.
• W2040227938 hasIssue "1" @default.
• W2040227938 hasLocation W20402279381 @default.
• W2040227938 hasLocation W20402279382 @default.
• W2040227938 hasLocation W20402279383 @default.
• W2040227938 hasLocation W20402279384 @default.
• W2040227938 hasOpenAccess W2040227938 @default.
• W2040227938 hasPrimaryLocation W20402279381 @default.
• W2040227938 hasRelatedWork W1995024643 @default.
• W2040227938 hasRelatedWork W2032102036 @default.
• W2040227938 hasRelatedWork W2037064786 @default.
• W2040227938 hasRelatedWork W2040227938 @default.

• next