Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040228465> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2040228465 endingPage "2871" @default.
- W2040228465 startingPage "2863" @default.
- W2040228465 abstract "The ability of sulphasalazine, its colonic metabolites and various analogues to inhibit prostaglandin inactivation by two purified preparations of type INAD+-dependent prostaglandin 15-hydroxydehydrogenase or in various 100,000 g cytosolic supernatants was investigated using PGF2 alpha as substrate and radio-TLC. Bovine lung and human placental PGDH were inhibited in a dose-dependent and apparently non-competitive manner by sulphasalazine and most of the 26 salazine/sulphasalazine analogues tested, but the potencies of the analogues varied considerably. In a survey of structure-activity effects testing 30 drugs at a fixed dose (50 microM) in six test systems, it was established that only two aromatic rings are needed and that optimal PGDH inhibition requires -CH2COOH and -OH at positions 1 and 2 in the salicyl C ring system. Homosalazine was thus established as the type compound of a novel series of powerful PGDH inhibitors. Electronegative substituents meta or para in ring B produce compounds with greater than 150 X inhibitory potency of sulphasalazine, and a significant linear correlation (r = 0.82, P less than 0.002) was found between the inhibitory activity and the Hammett sigma substituent constant in this series of ten homosalazine analogues." @default.
- W2040228465 created "2016-06-24" @default.
- W2040228465 creator A5017587054 @default.
- W2040228465 creator A5026438647 @default.
- W2040228465 creator A5045283404 @default.
- W2040228465 creator A5056636691 @default.
- W2040228465 date "1983-10-01" @default.
- W2040228465 modified "2023-09-28" @default.
- W2040228465 title "Inhibition of prostaglandin 15-hydroxydehydrogenase by sulphasalazine and a novel series of potent analogues" @default.
- W2040228465 cites W1971477105 @default.
- W2040228465 cites W1979915837 @default.
- W2040228465 cites W1991825338 @default.
- W2040228465 cites W1991903735 @default.
- W2040228465 cites W1994757981 @default.
- W2040228465 cites W1999445051 @default.
- W2040228465 cites W2004783754 @default.
- W2040228465 cites W2013296722 @default.
- W2040228465 cites W2024513902 @default.
- W2040228465 cites W2068625265 @default.
- W2040228465 cites W2397861637 @default.
- W2040228465 cites W2415775034 @default.
- W2040228465 cites W2438083907 @default.
- W2040228465 doi "https://doi.org/10.1016/0006-2952(83)90390-8" @default.
- W2040228465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6138042" @default.
- W2040228465 hasPublicationYear "1983" @default.
- W2040228465 type Work @default.
- W2040228465 sameAs 2040228465 @default.
- W2040228465 citedByCount "34" @default.
- W2040228465 countsByYear W20402284652012 @default.
- W2040228465 countsByYear W20402284652014 @default.
- W2040228465 countsByYear W20402284652015 @default.
- W2040228465 countsByYear W20402284652020 @default.
- W2040228465 crossrefType "journal-article" @default.
- W2040228465 hasAuthorship W2040228465A5017587054 @default.
- W2040228465 hasAuthorship W2040228465A5026438647 @default.
- W2040228465 hasAuthorship W2040228465A5045283404 @default.
- W2040228465 hasAuthorship W2040228465A5056636691 @default.
- W2040228465 hasConcept C185592680 @default.
- W2040228465 hasConcept C193042331 @default.
- W2040228465 hasConcept C202751555 @default.
- W2040228465 hasConcept C2776980637 @default.
- W2040228465 hasConcept C2777361909 @default.
- W2040228465 hasConcept C2778689049 @default.
- W2040228465 hasConcept C2780664492 @default.
- W2040228465 hasConcept C55493867 @default.
- W2040228465 hasConcept C57992300 @default.
- W2040228465 hasConcept C71240020 @default.
- W2040228465 hasConceptScore W2040228465C185592680 @default.
- W2040228465 hasConceptScore W2040228465C193042331 @default.
- W2040228465 hasConceptScore W2040228465C202751555 @default.
- W2040228465 hasConceptScore W2040228465C2776980637 @default.
- W2040228465 hasConceptScore W2040228465C2777361909 @default.
- W2040228465 hasConceptScore W2040228465C2778689049 @default.
- W2040228465 hasConceptScore W2040228465C2780664492 @default.
- W2040228465 hasConceptScore W2040228465C55493867 @default.
- W2040228465 hasConceptScore W2040228465C57992300 @default.
- W2040228465 hasConceptScore W2040228465C71240020 @default.
- W2040228465 hasIssue "19" @default.
- W2040228465 hasLocation W20402284651 @default.
- W2040228465 hasLocation W20402284652 @default.
- W2040228465 hasOpenAccess W2040228465 @default.
- W2040228465 hasPrimaryLocation W20402284651 @default.
- W2040228465 hasRelatedWork W1997341087 @default.
- W2040228465 hasRelatedWork W2010359051 @default.
- W2040228465 hasRelatedWork W2010623296 @default.
- W2040228465 hasRelatedWork W2037188214 @default.
- W2040228465 hasRelatedWork W2052557796 @default.
- W2040228465 hasRelatedWork W2077472737 @default.
- W2040228465 hasRelatedWork W2097588642 @default.
- W2040228465 hasRelatedWork W2125524835 @default.
- W2040228465 hasRelatedWork W2146767040 @default.
- W2040228465 hasRelatedWork W3007446011 @default.
- W2040228465 hasVolume "32" @default.
- W2040228465 isParatext "false" @default.
- W2040228465 isRetracted "false" @default.
- W2040228465 magId "2040228465" @default.
- W2040228465 workType "article" @default.