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- W2040228516 abstract "The capacity of osteoclasts to resorb bone depends, in part, on the surface expression of the integrin alpha v beta 3. We have investigated whether the steroid hormone retinoic acid, known to stimulate bone resorption, regulates the appearance of the alpha v beta 3 complex in avian osteoclast presursors. Using surface labeling, followed by immunoprecipitation with a alpha v beta 3-specific antibody, we show that retinoic acid increases surface expression of the heterodimer in a dose- and time-dependent manner. Northern analysis reveals that the high basal steady-state levels of alpha v mRNA do not change, while those for beta 3 rise significantly from their initially low levels. Nuclear run-on studies confirm that steroid treatment stimulates transcription of the beta 3, but not the alpha v gene. Osteoclast precursors treated with retinoic acid exhibit increased multinucleation and expression of the osteoclast marker enzyme tartrate-resistant acid phosphatase. However, the fused cells do not have an increased capacity to resorb bone. In summary, multinucleated cells generated in this study do not represent fully differentiated bone-resorbing polykaryons. These results suggest that treatment of osteoclast precursors with retinoic acid is necessary, but insufficient, for expression of the mature osteoclast phenotype." @default.
- W2040228516 created "2016-06-24" @default.
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- W2040228516 date "1996-09-15" @default.
- W2040228516 modified "2023-10-04" @default.
- W2040228516 title "Retinoic acid stimulates expression of the functional osteoclast integrin αvβ3: Transcriptional activation of the β3 but not the αv gene" @default.
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- W2040228516 doi "https://doi.org/10.1002/(sici)1097-4644(19960915)62:4<467::aid-jcb4>3.0.co;2-k" @default.
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