FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040229544> ?p ?o ?g. }

• W2040229544 endingPage "e976052" @default.
• W2040229544 startingPage "e976052" @default.
• W2040229544 abstract "Although tumor infiltrating lymphocyte (TIL) density is prognostic and predictive in colorectal cancer (CRC), the impact of tumor genetics upon colorectal immunobiology is unclear. Identification of genetic factors that influence the tumor immunophenotype is essential to improve the effectiveness of stratified immunotherapy approaches. We carried out a bioinformatics analysis of CRC data in The Cancer Genome Atlas (TCGA) involving two-dimensional hierarchical clustering to define an immune signature that we used to characterize the immune response across key patient groups. An immune signature termed The Co-ordinate Immune Response Cluster (CIRC) comprising 28 genes was coordinately regulated across the patient population. Four patient groups were delineated on the basis of cluster expression. Group A, which was heavily enriched for patients with microsatellite instability (MSI-H) and POL mutations, exhibited high CIRC expression, including the presence of several inhibitory molecules: CTLA4, PDL1, PDL2, LAG3, and TIM3. In contrast, RAS mutation was enriched in patient groups with lower CIRC expression. This work links the genetics and immunobiology of colorectal tumorigenesis, with implications for the development of stratified immunotherapeutic approaches. Microsatellite instability and POL mutations are linked with high mutational burden and high immune infiltration, but the coordinate expression of inhibitory pathways observed suggests combination checkpoint blockade therapy may be required to improve efficacy. In contrast, RAS mutant tumors predict for a relatively poor immune infiltration and low inhibitory molecule expression. In this setting, checkpoint blockade may be less efficacious, highlighting a requirement for novel strategies in this patient group." @default.
• W2040229544 created "2016-06-24" @default.
• W2040229544 creator A5023002127 @default.
• W2040229544 creator A5037541807 @default.
• W2040229544 creator A5044152755 @default.
• W2040229544 creator A5082226450 @default.
• W2040229544 date "2015-03-04" @default.
• W2040229544 modified "2023-09-30" @default.
• W2040229544 title "An immunogenomic stratification of colorectal cancer: Implications for development of targeted immunotherapy" @default.
• W2040229544 cites W1493822493 @default.
• W2040229544 cites W1501518736 @default.
• W2040229544 cites W1539270425 @default.
• W2040229544 cites W1966107523 @default.
• W2040229544 cites W1967663251 @default.
• W2040229544 cites W1971804207 @default.
• W2040229544 cites W1973076801 @default.
• W2040229544 cites W1985532701 @default.
• W2040229544 cites W2005154465 @default.
• W2040229544 cites W2019885702 @default.
• W2040229544 cites W2021472146 @default.
• W2040229544 cites W2040793402 @default.
• W2040229544 cites W2046182607 @default.
• W2040229544 cites W2051584526 @default.
• W2040229544 cites W2053967595 @default.
• W2040229544 cites W2055176101 @default.
• W2040229544 cites W2063521817 @default.
• W2040229544 cites W2068665896 @default.
• W2040229544 cites W2073504276 @default.
• W2040229544 cites W2077717095 @default.
• W2040229544 cites W2095598060 @default.
• W2040229544 cites W2101653483 @default.
• W2040229544 cites W2103547637 @default.
• W2040229544 cites W2110863884 @default.
• W2040229544 cites W2114843025 @default.
• W2040229544 cites W2119301589 @default.
• W2040229544 cites W2128627050 @default.
• W2040229544 cites W2130621814 @default.
• W2040229544 cites W2138397823 @default.
• W2040229544 cites W2139591061 @default.
• W2040229544 cites W2142300779 @default.
• W2040229544 cites W2144575133 @default.
• W2040229544 cites W2145606954 @default.
• W2040229544 cites W2148360952 @default.
• W2040229544 cites W2149441684 @default.
• W2040229544 cites W2155412969 @default.
• W2040229544 cites W2159187753 @default.
• W2040229544 cites W2160834915 @default.
• W2040229544 cites W2169499277 @default.
• W2040229544 cites W2171986697 @default.
• W2040229544 cites W2262414037 @default.
• W2040229544 cites W2330709704 @default.
• W2040229544 cites W4205811845 @default.
• W2040229544 doi "https://doi.org/10.4161/2162402x.2014.976052" @default.
• W2040229544 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4404815" @default.
• W2040229544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25949894" @default.
• W2040229544 hasPublicationYear "2015" @default.
• W2040229544 type Work @default.
• W2040229544 sameAs 2040229544 @default.
• W2040229544 citedByCount "78" @default.
• W2040229544 countsByYear W20402295442015 @default.
• W2040229544 countsByYear W20402295442016 @default.
• W2040229544 countsByYear W20402295442017 @default.
• W2040229544 countsByYear W20402295442018 @default.
• W2040229544 countsByYear W20402295442019 @default.
• W2040229544 countsByYear W20402295442020 @default.
• W2040229544 countsByYear W20402295442021 @default.
• W2040229544 countsByYear W20402295442022 @default.
• W2040229544 countsByYear W20402295442023 @default.
• W2040229544 crossrefType "journal-article" @default.
• W2040229544 hasAuthorship W2040229544A5023002127 @default.
• W2040229544 hasAuthorship W2040229544A5037541807 @default.
• W2040229544 hasAuthorship W2040229544A5044152755 @default.
• W2040229544 hasAuthorship W2040229544A5082226450 @default.
• W2040229544 hasBestOaLocation W20402295441 @default.
• W2040229544 hasConcept C104317684 @default.
• W2040229544 hasConcept C121608353 @default.
• W2040229544 hasConcept C13514818 @default.
• W2040229544 hasConcept C143998085 @default.
• W2040229544 hasConcept C180754005 @default.
• W2040229544 hasConcept C203014093 @default.
• W2040229544 hasConcept C2777701055 @default.
• W2040229544 hasConcept C2779767149 @default.
• W2040229544 hasConcept C2780674031 @default.
• W2040229544 hasConcept C2780851360 @default.
• W2040229544 hasConcept C2908647359 @default.
• W2040229544 hasConcept C501734568 @default.
• W2040229544 hasConcept C502942594 @default.
• W2040229544 hasConcept C526805850 @default.
• W2040229544 hasConcept C54355233 @default.
• W2040229544 hasConcept C555283112 @default.
• W2040229544 hasConcept C60748783 @default.
• W2040229544 hasConcept C61320498 @default.
• W2040229544 hasConcept C71924100 @default.
• W2040229544 hasConcept C86803240 @default.
• W2040229544 hasConcept C8891405 @default.
• W2040229544 hasConcept C99454951 @default.
• W2040229544 hasConceptScore W2040229544C104317684 @default.
• W2040229544 hasConceptScore W2040229544C121608353 @default.

• next