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• W2040233076 abstract "This study was carried out to characterize HIV-1 reverse transcriptase (RT) mutations in vertically infected infants in Jos, Nigeria. DNA was extracted from peripheral blood mononuclear cells of 102 infants, aged 0 to 6 months, born to HIV-1-infected mothers who had received peripartum single-dose nevirapine prophylaxis. PCR-based diagnosis revealed that 14 infants (13.7%) were infected with HIV-1. Phylogenetic analyses of RT revealed wide viral diversity, with CRF02_AG, subtype G, subsubtype A3, CRF06_cpx, and a subtype D recombinant present in the population. Four of 13 (31%) infants had NNRTI resistance mutations––V179I (2 infants), Y181C, and V179E. Intriguingly, subtype G sequences did not have NNRTI mutations but rather carried a Q207N mutation, which may undergo negative selection under drug pressure. Our data suggest wide diversity for vertically transmitted HIV-1 viruses in Nigeria and highlight the potential significance of transmitting rare mutations in subtype G." @default.
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• W2040233076 date "2007-12-01" @default.
• W2040233076 modified "2023-10-16" @default.
• W2040233076 title "Characterization of HIV Type 1 Reverse Transcriptase Mutations in Infants Infected by Mothers Who Received Peripartum Nevirapine Prophylaxis in Jos, Nigeria" @default.
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• W2040233076 doi "https://doi.org/10.1089/aid.2007.0064" @default.
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