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• W2040234260 startingPage "2329" @default.
• W2040234260 abstract "Endocrine therapy is the mainstay of adjuvant treatment for hormonereceptor-positive early breast cancer. Letrozole is a potent third-generation aromatase inhibitor that suppresses plasma estrogen levels to near-undetectable levels in postmenopausal women. The results of well-controlled clinical trials have demonstrated the efficacy of letrozole over the gold-standard treatment, tamoxifen, in the neoadjuvant and upfront adjuvant settings and over placebo in the extended adjuvant setting (i.e., following 5 years of adjuvant tamoxifen). Important benefits in disease-free survival and especially distant disease-free survival have been demonstrated, in both low- and high-risk subgroups of patients (e.g., node-positive disease, prior chemotherapy). Both the efficacy and safety of letrozole for the adjuvant treatment of breast cancer are reviewed." @default.
• W2040234260 created "2016-06-24" @default.
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• W2040234260 date "2007-10-01" @default.
• W2040234260 modified "2023-10-18" @default.
• W2040234260 title "Update on the use of letrozole in breast cancer" @default.
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• W2040234260 doi "https://doi.org/10.1517/14656566.8.14.2329" @default.
• W2040234260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17927487" @default.
• W2040234260 hasPublicationYear "2007" @default.
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