FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040239587> ?p ?o ?g. }

• W2040239587 endingPage "686" @default.
• W2040239587 startingPage "677" @default.
• W2040239587 abstract "Benztropine (BZT) analogs inhibit dopamine uptake but are less effective than cocaine in producing behavioral effects predicting abuse liability. The present study compared reinforcing effects of intravenous BZT analogs with those of standard monoamine uptake inhibitors and the effects of their oral pretreatment on cocaine self-administration. Responding of rats was maintained by cocaine [0.032-1.0 mg/kg/injection (inj)] or food reinforcement under fixed-ratio five-response schedules. Maximal rates of responding were maintained by 0.32 mg/kg/inj cocaine or substituted methylphenidate, with lower rates maintained at lower and higher doses. The N-methyl BZT analog, AHN 1-055 (3alpha-[bis(4'-fluorophenyl)methoxy]-tropane), also maintained responding (0.1 mg/kg/inj), although maximal rates were less than those with cocaine. Responding was not maintained above vehicle levels by the N-allyl, AHN 2-005 (N-allyl-3alpha-[bis(4'-fluorophenyl)methoxy]-tropane), and N-butyl, JHW 007 [N-(n-butyl)-3alpha-[bis(4'-fluorophenyl)methoxy]-tropane], BZT analogs, and it was not maintained with nisoxetine or citalopram. Presession treatment with methylphenidate (3.2-32 mg/kg) dose-dependently shifted the cocaine self-administration dose-effect curve leftward, whereas nisoxetine and citalopram effects were not significant. An intermediate dose of AHN 1-055 (32 mg/kg) increased responding maintained by low cocaine doses and decreased responding maintained by higher doses. A higher dose of AHN 1-055 completely suppressed cocaine-maintained responding. Both AHN 2-005 and JHW 007 dose-dependently (10-32 mg/kg) decreased cocaine self-administration, shifting its dose-effect curve down. Decreases in cocaine-maintained responding occurred at doses of methylphenidate and BZT analogs that left food-maintained responding unchanged. During a component in which injections were not available, methylphenidate and AHN 1-055, but not AHN 2-005 or JHW 007, increased response rates. These findings further support the low abuse liability of BZT analogs and their potential development as medications for cocaine abuse." @default.
• W2040239587 created "2016-06-24" @default.
• W2040239587 creator A5025423982 @default.
• W2040239587 creator A5061926206 @default.
• W2040239587 creator A5067751090 @default.
• W2040239587 creator A5079499460 @default.
• W2040239587 date "2009-02-19" @default.
• W2040239587 modified "2023-10-16" @default.
• W2040239587 title "Assessment of Reinforcing Effects of Benztropine Analogs and Their Effects on Cocaine Self-Administration in Rats: Comparisons with Monoamine Uptake Inhibitors" @default.
• W2040239587 cites W1963787385 @default.
• W2040239587 cites W1976323601 @default.
• W2040239587 cites W1980014219 @default.
• W2040239587 cites W1980599051 @default.
• W2040239587 cites W1981462241 @default.
• W2040239587 cites W1993584299 @default.
• W2040239587 cites W1999331154 @default.
• W2040239587 cites W2006691722 @default.
• W2040239587 cites W2013139515 @default.
• W2040239587 cites W2019647316 @default.
• W2040239587 cites W2023042672 @default.
• W2040239587 cites W2025611728 @default.
• W2040239587 cites W2028857574 @default.
• W2040239587 cites W2029074767 @default.
• W2040239587 cites W2029516351 @default.
• W2040239587 cites W2030442976 @default.
• W2040239587 cites W2031759800 @default.
• W2040239587 cites W2041016454 @default.
• W2040239587 cites W2052351662 @default.
• W2040239587 cites W2056559453 @default.
• W2040239587 cites W2060997506 @default.
• W2040239587 cites W2062951524 @default.
• W2040239587 cites W2071328685 @default.
• W2040239587 cites W2076326412 @default.
• W2040239587 cites W2084635427 @default.
• W2040239587 cites W2095217951 @default.
• W2040239587 cites W2120664223 @default.
• W2040239587 cites W2131202975 @default.
• W2040239587 cites W2131577533 @default.
• W2040239587 cites W2137614509 @default.
• W2040239587 cites W2145714767 @default.
• W2040239587 cites W2159965031 @default.
• W2040239587 cites W2162580726 @default.
• W2040239587 cites W4248023311 @default.
• W2040239587 doi "https://doi.org/10.1124/jpet.108.145813" @default.
• W2040239587 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2672867" @default.
• W2040239587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19228996" @default.
• W2040239587 hasPublicationYear "2009" @default.
• W2040239587 type Work @default.
• W2040239587 sameAs 2040239587 @default.
• W2040239587 citedByCount "86" @default.
• W2040239587 countsByYear W20402395872012 @default.
• W2040239587 countsByYear W20402395872013 @default.
• W2040239587 countsByYear W20402395872014 @default.
• W2040239587 countsByYear W20402395872015 @default.
• W2040239587 countsByYear W20402395872016 @default.
• W2040239587 countsByYear W20402395872017 @default.
• W2040239587 countsByYear W20402395872018 @default.
• W2040239587 countsByYear W20402395872019 @default.
• W2040239587 countsByYear W20402395872020 @default.
• W2040239587 countsByYear W20402395872021 @default.
• W2040239587 countsByYear W20402395872022 @default.
• W2040239587 crossrefType "journal-article" @default.
• W2040239587 hasAuthorship W2040239587A5025423982 @default.
• W2040239587 hasAuthorship W2040239587A5061926206 @default.
• W2040239587 hasAuthorship W2040239587A5067751090 @default.
• W2040239587 hasAuthorship W2040239587A5079499460 @default.
• W2040239587 hasBestOaLocation W20402395872 @default.
• W2040239587 hasConcept C118552586 @default.
• W2040239587 hasConcept C126322002 @default.
• W2040239587 hasConcept C15744967 @default.
• W2040239587 hasConcept C170493617 @default.
• W2040239587 hasConcept C185592680 @default.
• W2040239587 hasConcept C187714386 @default.
• W2040239587 hasConcept C2775864247 @default.
• W2040239587 hasConcept C2776552330 @default.
• W2040239587 hasConcept C2776995303 @default.
• W2040239587 hasConcept C2777112843 @default.
• W2040239587 hasConcept C2777490545 @default.
• W2040239587 hasConcept C2778555786 @default.
• W2040239587 hasConcept C2780035454 @default.
• W2040239587 hasConcept C2780783007 @default.
• W2040239587 hasConcept C2908949072 @default.
• W2040239587 hasConcept C2910393698 @default.
• W2040239587 hasConcept C3018251022 @default.
• W2040239587 hasConcept C513476851 @default.
• W2040239587 hasConcept C55493867 @default.
• W2040239587 hasConcept C71240020 @default.
• W2040239587 hasConcept C71924100 @default.
• W2040239587 hasConcept C98274493 @default.
• W2040239587 hasConceptScore W2040239587C118552586 @default.
• W2040239587 hasConceptScore W2040239587C126322002 @default.
• W2040239587 hasConceptScore W2040239587C15744967 @default.
• W2040239587 hasConceptScore W2040239587C170493617 @default.
• W2040239587 hasConceptScore W2040239587C185592680 @default.
• W2040239587 hasConceptScore W2040239587C187714386 @default.
• W2040239587 hasConceptScore W2040239587C2775864247 @default.
• W2040239587 hasConceptScore W2040239587C2776552330 @default.
• W2040239587 hasConceptScore W2040239587C2776995303 @default.

• next