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• W2040241746 abstract "Two forms of human tryptophanyl-tRNA synthetase (TrpRS) are produced in vivo through alternative mRNA splicing. The two forms, full-length TrpRS and mini TrpRS, are catalytically active, but are distinguished by the striking anti-proliferative and anti-angiogenic activity specific to mini TrpRS. Here we describe two new splice variants of human TrpRS mRNA. Their production was strongly regulated by gamma-interferon (IFN-gamma), an anti-proliferative cytokine known to stimulate the expression of other anti-angiogenic factors. A new IFN-gamma-sensitive promoter was demonstrated to drive production of these splice variants. In human endothelial cells, both the newly discovered and a previously reported promoter were shown to respond specifically to IFN-gamma and not to other cytokines such as tumor necrosis factor-alpha, transforming growth factor-beta, interleukin-4 or erythropoietin. In addition, both promoters were stimulated by the 'downstream' interferon regulatory factor 1 that, in turn, is known to be regulated by the 'upstream' signal transducer and activator of transcription 1alpha subunit. Thus, the tandem promoters provide a dual system to regulate expression and alternative splicing of human TrpRS in vivo." @default.
• W2040241746 created "2016-06-24" @default.
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• W2040241746 date "2004-01-21" @default.
• W2040241746 modified "2023-10-16" @default.
• W2040241746 title "A new -interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase" @default.
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• W2040241746 doi "https://doi.org/10.1093/nar/gkh240" @default.
• W2040241746 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/373357" @default.
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• W2040241746 hasPublicationYear "2004" @default.
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