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• W2040245115 abstract "A parallel clinical and behavioral study of adjuvant-induced arthritis in the rat showed four stages in the time-course of the disease: preclinical (first week), acute (weeks 2–4), post-acute (weeks 5–8) and recovery weeks 9–11) [Calvino et al. (1987) Behav. Brain Res.24, 11–29]. As several studies have reported the expression of the proto-oncogene c-fos in spinal cord neurons following acute noxious peripheral stimuli, the aim of this study was to quantitatively assess Fos-like immunoreactivity in lumbar spinal cord neurons at various times of adjuvant-induced arthritis development, i.e. one, two, three, 11 and 22 weeks post-inoculation. The total number of Fos-like immunoreactive neurons in the lumbar enlargement correlated with the observed development of adjuvant-induced arthritis, i.e. Fos-like immunoreactivity was absent at one week, moderate at two weeks, greatly increased at three weeks, decreased at 11 weeks and returned to control values at 22 weeks. At three weeks, at the peak of Fos-like immunoreactivity distribution and acute stage of hyperalgesia, maximal labeling was observed in L3 and L4 spinal segments. In these segments, the most densely labeled region was the neck (laminae V and VI) of the dorsal horn (55%) and the ventral horn (35%) as compared to the superficial laminae (laminae I and II; 5%) and the nucleus proprius (laminae III and IV; 5%). These data indicate that c-fos expression induced by chronic inflammation is better expressed in deeper laminae than in the superficial ones, and that the number of Fos-positive cells correlates with behavioral studies. Thus, the use of Fos-like immunoreactivity in the chronic inflammatory pain model seems to be an interesting tool to study possible effects of various pharmacological compounds such as analgesic or anti-inflammatory drugs." @default.
• W2040245115 created "2016-06-24" @default.
• W2040245115 creator A5008895579 @default.
• W2040245115 creator A5056963078 @default.
• W2040245115 date "1992-06-01" @default.
• W2040245115 modified "2023-10-18" @default.
• W2040245115 title "c-fos Expression in rat lumbar spinal cord during the development of adjuvant-induced arthritis" @default.
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• W2040245115 doi "https://doi.org/10.1016/0306-4522(92)90287-c" @default.
• W2040245115 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1630632" @default.
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