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- W2040245788 abstract "The interactions between the intracellular metabolome, fluxome and growth rate of Escherichia coli after sudden glycolytic/gluconeogenic substrate shifts are studied based on pulses of different substrates to an aerobic glucose-limited steady-state (dilution rate=0.1 h−1). After each added glycolytic (glucose) and gluconeogenic (pyruvate and succinate) substrate pulse, no by-products were secreted and a pseudo steady state in flux and metabolites was achieved in about 30–40 s. In the pulse experiments a large oxygen uptake capacity of the cells was observed. The in vivo dynamic responses showed massive reorganization and flexibility (1/100–14-fold change) of extra/intracellular metabolic fluxes, matching with large changes in the concentrations of intracellular metabolites, including reversal of reaction rate for pseudo/near equilibrium reactions. The coupling of metabolome and fluxome could be described by Q-linear kinetics. Remarkably, the three different substrate pulses resulted in a very similar increase in growth rate (0.13–0.3 h−1). Data analysis showed that there must exist as yet unknown mechanisms which couple the protein synthesis rate to changes in central metabolites." @default.
- W2040245788 created "2016-06-24" @default.
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- W2040245788 date "2013-03-01" @default.
- W2040245788 modified "2023-09-26" @default.
- W2040245788 title "Changes in substrate availability in Escherichia coli lead to rapid metabolite, flux and growth rate responses" @default.
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- W2040245788 doi "https://doi.org/10.1016/j.ymben.2013.01.004" @default.
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