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• W2040246945 endingPage "123" @default.
• W2040246945 startingPage "116" @default.
• W2040246945 abstract "Chromium is a potent human carcinogen, probably because of its well-documented genotoxic effects. Chromate (Cr[VI]) causes a wide range of DNA lesions, including DNA crosslinks and strand breaks, presumably due to the direct and indirect effects of DNA oxidation. Homologous recombination repair (HRR) is important for error-free repair of lesions occurring at replication forks. Here, we show that HR deficient cell lines irs1SF and V-C8, deficient in XRCC3 and BRCA2, respectively, are hypersensitive to Cr[VI], implicating this repair pathway in repair of Cr[VI] damage. Furthermore, we find that Cr[VI] causes DNA double-strand breaks and triggers both Rad51 foci formation and induction of HRR. Collectively, these data suggest that HRR is important in repair of Cr[VI]-induced DNA damage. In addition, we find that ERCC1, XRCC1 and DNA-PKcs defective cells are hypersensitive to Cr[VI], indicating that several repair pathways cooperate in repairing Cr[VI]-induced DNA damage." @default.
• W2040246945 created "2016-06-24" @default.
• W2040246945 creator A5029296072 @default.
• W2040246945 creator A5059215689 @default.
• W2040246945 creator A5073511034 @default.
• W2040246945 date "2006-07-01" @default.
• W2040246945 modified "2023-10-12" @default.
• W2040246945 title "Homologous recombination is involved in repair of chromium-induced DNA damage in mammalian cells" @default.
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• W2040246945 doi "https://doi.org/10.1016/j.mrfmmm.2006.02.001" @default.
• W2040246945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16564059" @default.
• W2040246945 hasPublicationYear "2006" @default.
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