Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040248319> ?p ?o ?g. }
- W2040248319 endingPage "e103725" @default.
- W2040248319 startingPage "e103725" @default.
- W2040248319 abstract "A crucial step in generating de novo immune responses is the polarization of naive cognate CD4+ T cells by pathogen-triggered dendritic cells (DC). In the human setting, standardized DC-dependent systems are lacking to study molecular events during the initiation of a naive CD4+ T cell response. We developed a TCR-restricted assay to compare different pathogen-triggered human DC for their capacities to instruct functional differentiation of autologous, naive CD4+ T cells. We demonstrated that this methodology can be applied to compare differently matured DC in terms of kinetics, direction, and magnitude of the naive CD4+ T cell response. Furthermore, we showed the applicability of this assay to study the T cell polarizing capacity of low-frequency blood-derived DC populations directly isolated ex vivo. This methodology for addressing APC-dependent instruction of naive CD4+ T cells in a human autologous setting will provide researchers with a valuable tool to gain more insight into molecular mechanisms occurring in the early phase of T cell polarization. In addition, it may also allow the study of pharmacological agents on DC-dependent T cell polarization in the human system." @default.
- W2040248319 created "2016-06-24" @default.
- W2040248319 creator A5000278145 @default.
- W2040248319 creator A5002849742 @default.
- W2040248319 creator A5007487857 @default.
- W2040248319 creator A5017315652 @default.
- W2040248319 creator A5040923307 @default.
- W2040248319 creator A5082157943 @default.
- W2040248319 date "2014-08-21" @default.
- W2040248319 modified "2023-10-05" @default.
- W2040248319 title "Monitoring the Initiation and Kinetics of Human Dendritic Cell-Induced Polarization of Autologous Naive CD4+ T Cells" @default.
- W2040248319 cites W1495801953 @default.
- W2040248319 cites W1510730676 @default.
- W2040248319 cites W1556530772 @default.
- W2040248319 cites W1579010799 @default.
- W2040248319 cites W1601925808 @default.
- W2040248319 cites W1604795805 @default.
- W2040248319 cites W1639524701 @default.
- W2040248319 cites W1667453974 @default.
- W2040248319 cites W1934183467 @default.
- W2040248319 cites W1942668068 @default.
- W2040248319 cites W1964267076 @default.
- W2040248319 cites W1967261754 @default.
- W2040248319 cites W1971872860 @default.
- W2040248319 cites W1981087308 @default.
- W2040248319 cites W1982752226 @default.
- W2040248319 cites W1985498297 @default.
- W2040248319 cites W1987146610 @default.
- W2040248319 cites W1987598047 @default.
- W2040248319 cites W1990233086 @default.
- W2040248319 cites W1991147696 @default.
- W2040248319 cites W1992851412 @default.
- W2040248319 cites W1999070120 @default.
- W2040248319 cites W2004773897 @default.
- W2040248319 cites W2012680181 @default.
- W2040248319 cites W2023922058 @default.
- W2040248319 cites W2024490058 @default.
- W2040248319 cites W2032188826 @default.
- W2040248319 cites W2032875252 @default.
- W2040248319 cites W2038271225 @default.
- W2040248319 cites W2045717244 @default.
- W2040248319 cites W2046544258 @default.
- W2040248319 cites W2047949586 @default.
- W2040248319 cites W2050034605 @default.
- W2040248319 cites W2052079689 @default.
- W2040248319 cites W2052997401 @default.
- W2040248319 cites W2054626826 @default.
- W2040248319 cites W2055932480 @default.
- W2040248319 cites W2062388977 @default.
- W2040248319 cites W2067200709 @default.
- W2040248319 cites W2068290887 @default.
- W2040248319 cites W2068674690 @default.
- W2040248319 cites W2069981713 @default.
- W2040248319 cites W2078450673 @default.
- W2040248319 cites W2087494999 @default.
- W2040248319 cites W2094158049 @default.
- W2040248319 cites W2104904748 @default.
- W2040248319 cites W2105108488 @default.
- W2040248319 cites W2109491705 @default.
- W2040248319 cites W2116655656 @default.
- W2040248319 cites W2126397566 @default.
- W2040248319 cites W2128149258 @default.
- W2040248319 cites W2134702933 @default.
- W2040248319 cites W2136757504 @default.
- W2040248319 cites W2144890743 @default.
- W2040248319 cites W2148044949 @default.
- W2040248319 cites W2151566115 @default.
- W2040248319 cites W2152201021 @default.
- W2040248319 cites W2158820015 @default.
- W2040248319 cites W2159421887 @default.
- W2040248319 cites W2159514218 @default.
- W2040248319 cites W2160258620 @default.
- W2040248319 cites W2160655212 @default.
- W2040248319 cites W2161767894 @default.
- W2040248319 cites W2167366928 @default.
- W2040248319 cites W2264976931 @default.
- W2040248319 cites W4248354276 @default.
- W2040248319 doi "https://doi.org/10.1371/journal.pone.0103725" @default.
- W2040248319 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4140687" @default.
- W2040248319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25144736" @default.
- W2040248319 hasPublicationYear "2014" @default.
- W2040248319 type Work @default.
- W2040248319 sameAs 2040248319 @default.
- W2040248319 citedByCount "7" @default.
- W2040248319 countsByYear W20402483192015 @default.
- W2040248319 countsByYear W20402483192016 @default.
- W2040248319 countsByYear W20402483192017 @default.
- W2040248319 countsByYear W20402483192018 @default.
- W2040248319 countsByYear W20402483192022 @default.
- W2040248319 countsByYear W20402483192023 @default.
- W2040248319 crossrefType "journal-article" @default.
- W2040248319 hasAuthorship W2040248319A5000278145 @default.
- W2040248319 hasAuthorship W2040248319A5002849742 @default.
- W2040248319 hasAuthorship W2040248319A5007487857 @default.
- W2040248319 hasAuthorship W2040248319A5017315652 @default.
- W2040248319 hasAuthorship W2040248319A5040923307 @default.
- W2040248319 hasAuthorship W2040248319A5082157943 @default.
- W2040248319 hasBestOaLocation W20402483191 @default.