Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040250147> ?p ?o ?g. }
- W2040250147 endingPage "732" @default.
- W2040250147 startingPage "720" @default.
- W2040250147 abstract "Non-neuronal factors such as angiogenesis and neuroinflammation may play a role in l-dopa induced dyskinesias (LID). Vascular endothelial growth factor (VEGF) and proinflammatory cytokines such as interleukin-1β (IL-1β) have been found to be involved in LID. The renin-angiotensin system (RAS) is involved in the inflammatory response and VEGF synthesis via type 1 (AT1) receptors. However, it is not known whether the RAS plays a role in LID and whether AT1 antagonists could constitute a useful therapy against LID. In this study, we investigated whether manipulation of brain RAS is effective in preventing LID. Blocking AT1 receptors with candesartan significantly reduces LID in the 6-OHDA rat model. Chronic dopaminergic denervation induces an increase in striatal levels of VEGF and IL-1β. Dyskinetic animals showed significantly higher levels of VEGF and IL-1β in the lateral striatum and the substantia nigra, as revealed by western blot and real time-PCR analyses. Interestingly, animals treated with both candesartan and l-dopa displayed significantly lower levels of VEGF, IL-1β and dyskinesia than those treated with l-dopa alone. The stimulatory effect of angiotensin II (AII) on VEGF expression was confirmed by the addition of AII to primary mesencephalic cultures and intraventricular administration of AII in rats. The results of the present study reveal for the first time that blockage of AT-1 receptors reduces LID. A candesartan-induced decrease in VEGF and IL-1β may be responsible for the beneficial effects, suggesting the brain RAS as a new target for LID treatment in PD patients." @default.
- W2040250147 created "2016-06-24" @default.
- W2040250147 creator A5005884041 @default.
- W2040250147 creator A5011189425 @default.
- W2040250147 creator A5018968087 @default.
- W2040250147 creator A5057756574 @default.
- W2040250147 date "2014-11-01" @default.
- W2040250147 modified "2023-10-13" @default.
- W2040250147 title "Angiotensin type 1 receptor blockage reduces l-dopa-induced dyskinesia in the 6-OHDA model of Parkinson's disease. Involvement of vascular endothelial growth factor and interleukin-1β" @default.
- W2040250147 cites W1528597597 @default.
- W2040250147 cites W1529501189 @default.
- W2040250147 cites W1538480909 @default.
- W2040250147 cites W1545110321 @default.
- W2040250147 cites W1549834656 @default.
- W2040250147 cites W1570444420 @default.
- W2040250147 cites W1799696262 @default.
- W2040250147 cites W1894493322 @default.
- W2040250147 cites W1957113176 @default.
- W2040250147 cites W1964087924 @default.
- W2040250147 cites W1964312575 @default.
- W2040250147 cites W1964830694 @default.
- W2040250147 cites W1966260988 @default.
- W2040250147 cites W1966443363 @default.
- W2040250147 cites W1967709130 @default.
- W2040250147 cites W1968306269 @default.
- W2040250147 cites W1969435326 @default.
- W2040250147 cites W1977327589 @default.
- W2040250147 cites W1981532847 @default.
- W2040250147 cites W1985712533 @default.
- W2040250147 cites W1989475543 @default.
- W2040250147 cites W1991935832 @default.
- W2040250147 cites W1995495792 @default.
- W2040250147 cites W1998880668 @default.
- W2040250147 cites W1999009908 @default.
- W2040250147 cites W1999080810 @default.
- W2040250147 cites W1999401390 @default.
- W2040250147 cites W2000292756 @default.
- W2040250147 cites W2002851005 @default.
- W2040250147 cites W2010206955 @default.
- W2040250147 cites W2011643486 @default.
- W2040250147 cites W2016023748 @default.
- W2040250147 cites W2016107840 @default.
- W2040250147 cites W2017213641 @default.
- W2040250147 cites W2017424741 @default.
- W2040250147 cites W2021356347 @default.
- W2040250147 cites W2023701287 @default.
- W2040250147 cites W2023942502 @default.
- W2040250147 cites W2024639041 @default.
- W2040250147 cites W2025343582 @default.
- W2040250147 cites W2033091119 @default.
- W2040250147 cites W2036940243 @default.
- W2040250147 cites W2037912913 @default.
- W2040250147 cites W2038773105 @default.
- W2040250147 cites W2039190334 @default.
- W2040250147 cites W2039857463 @default.
- W2040250147 cites W2040763549 @default.
- W2040250147 cites W2041164650 @default.
- W2040250147 cites W2044280075 @default.
- W2040250147 cites W2052343454 @default.
- W2040250147 cites W2053844486 @default.
- W2040250147 cites W2056266675 @default.
- W2040250147 cites W2056304640 @default.
- W2040250147 cites W2060619513 @default.
- W2040250147 cites W2063235610 @default.
- W2040250147 cites W2063559455 @default.
- W2040250147 cites W2069515205 @default.
- W2040250147 cites W2070654072 @default.
- W2040250147 cites W2078331588 @default.
- W2040250147 cites W2084532446 @default.
- W2040250147 cites W2085137779 @default.
- W2040250147 cites W2085955635 @default.
- W2040250147 cites W2095019266 @default.
- W2040250147 cites W2097863680 @default.
- W2040250147 cites W2102560431 @default.
- W2040250147 cites W2102744645 @default.
- W2040250147 cites W2103299168 @default.
- W2040250147 cites W2103757082 @default.
- W2040250147 cites W2103829023 @default.
- W2040250147 cites W2104246889 @default.
- W2040250147 cites W2105400389 @default.
- W2040250147 cites W2107574028 @default.
- W2040250147 cites W2110539420 @default.
- W2040250147 cites W2115613566 @default.
- W2040250147 cites W2123779772 @default.
- W2040250147 cites W2127087387 @default.
- W2040250147 cites W2127460667 @default.
- W2040250147 cites W2132039169 @default.
- W2040250147 cites W2136632794 @default.
- W2040250147 cites W2138535275 @default.
- W2040250147 cites W2139972295 @default.
- W2040250147 cites W2142430425 @default.
- W2040250147 cites W2143579316 @default.
- W2040250147 cites W2146173262 @default.
- W2040250147 cites W2146768696 @default.
- W2040250147 cites W2148874697 @default.
- W2040250147 cites W2149413458 @default.
- W2040250147 cites W2154011816 @default.
- W2040250147 cites W2160532761 @default.