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• W2040254075 abstract "HepatologyVolume 6, Issue 2 p. 316-319 EditorialFree Access Hepatic drug metabolism in the elderly Kenichi Kitani M.D., Corresponding Author Kenichi Kitani M.D. First Laboratory of Clinical Physiology Tokyo Metropolitan Institute of Gerontology 35–2, Sakaecho, Itabashi-ku Tokyo, JapanFirst Laboratory of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, 35–2, Sakaecho, Itabashi-ku, Tokyo, Japan===Search for more papers by this author Kenichi Kitani M.D., Corresponding Author Kenichi Kitani M.D. First Laboratory of Clinical Physiology Tokyo Metropolitan Institute of Gerontology 35–2, Sakaecho, Itabashi-ku Tokyo, JapanFirst Laboratory of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, 35–2, Sakaecho, Itabashi-ku, Tokyo, Japan===Search for more papers by this author First published: March/April 1986 https://doi.org/10.1002/hep.1840060227Citations: 23AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Hofman AF. The aminopyrine demethylation breath test and the serum bile acid level: nominated but not yet elected to join the common liver tests. Hepatology 1982; 2: 512–517. 2 Seidl LG, Thornton GF, Smith JW, et al. Studies on the epidemiology of adverse drug reactions. 111. Reactions in patients on a general medical service. Bull Johns Hopkins Hosp 1966 119: 299–315. 3 Hurwitz N. Predisposing factors in adverse reactions to drugs. Br Med J 1969; 1: 536–539. 4 Miller RR. Drug surveillance utilizing epidemiologic methods: a report from the Boston Collaborative Drug Surveillance Program. Am J Hop Pharm 1973; 30: 584–592. 5 Vestal RE, Wood AJJ, Branch RA, et al. Studies of drug disposition in the elderly using model compounds. In: K Kitani. Liver and aging 1978. Amsterdam: Elsevier/North-Holland, 1978 343–357. 6 Greenblatt DJ, Sellers EM, Shader RI. Drug disposition in old age. N Engl J Med 1982; 306: 1081–1088. 7 Klotz U, Bruckel KW. Pharmacokinetics and pharmacodynamics in the elderly. In: K Kitani, ed. Liver and aging-1982, Liver and adrugs. Amsterdam: Elsevier Biomedical Press, 1982: 287–299, 8 Kato R, Vassanelli P, Frontino G, et al. Variation in the activity of liver microsomal drug metabolizing enzymes in rats in relation ato the age. Biochem Pharmacol 1964; 13: 1037–1051. 9 Kato R, Takanaka A. Metabolism of drugs in old rats. I. Activities of NADPH linked electron transport and drugmetabolizing en- zyme systems in liver microsomes of old rats. Jpn J Pharmacol 1968; 18: 381–388. 10 Kato R, Takanaka A, Onoda K. Studies on age differences in mice for the activity of drug-metabolizing enzymes of liver microsomes. Jpn d Pharmacol 1970; 20: 572–576. Jpn d Pharmacol 1970; 18: 381–388. 11 Kao J, Hudson P. Induction of the hepatic cytochrome P-450 dependent mono-oxygenase system in young and geriatric rats. Biochem Pharmacol 1980; 29: 1191–1194. 12 Rikans LE, Notley BA. Age-related changes in hepatic microsomal drug metabolism are substrate selective. J Pharmacol Exp Ther 1982; 220: 574–578. 13 Fujita S, Uesugi T, Kitagawa H, et al. Hepatic microsomal monooxygenase and azoreductase activities in aging F-344 rats. Importance of sex difference for aging studies. In: K Kitani, ed. Liver and aging–1982, Liver and drugs. Amsterdam: Elsevier Biomedical Press, 1982: 55–74. 14 Fujita S, Tatsuno J, Kawai R, et al. Age associated alteration of lidocaine metabolism is position selective. Biochem Biophys Res Commun 1985; 126: 117–122. 15 Schmucker DL. Age-related changes in drug disposition. Pharmacol Rev 1979; 30: 445–456. 16 Van Bezooijen CFA. Influence of age-related changes in rodent liver morphology and physiology on drug metabolism–A review. Mech Ageing Develop 1984; 25: 1–22. 17 Kitani K. Drugs and aging liver–a critical reevaluation of rodent studies. In: CFA van Bezooijen, ed. Proc EURAGE Workshop on Pharmacological Morphological and Physiological Aspects of Liver Aging. Rijswijk, The Netherlands: EURAGE, 1984: 105–114. 18 Kitani K. The effect of age on hepatic drug metabolism of xenobiotics. In: J Caldwell, G Paulson, eds. Foreign compound metabolism. London: Taylor and Francis, 1984: 12–25. 19 Stier A, Finch SAE, Greinert R, et al. Membrane structure and function of the hepatic microsomal cytochrome P-450 system. In: K Kitani, ed. Liver and aging–1982, Liver and drugs. Amsterdam: Elsevier Biomedical Press, 1982: 3–17. 20 Schmucker DL, Vessey DA, Wang RK, et al. Age-dependent alterations in the physicochemical properties of rat liver microsomes. Mech Ageing Develop 1984: 27: 207–217. 21 Schmucker DL, Wang RK. Age-dependent alterations in rat liver microsomal NADPH cytochrome c (P-450) reductase: a qualitative and quantitative analysis. Mech Ageing Develop 1983; 21: 137–156. 22 Kamataki T, Maeda K, Shimada M, et al. Age-related alteration in the activities of drug-metabolizing enzymes and contents of sex-specific forms of cytochrome P-450 in liver microsomes from male and female rats. J Pharmacol Exp Ther 1985; 233: 222–228. 23 Fujita T, Kitagawa H, Chiba M, et al. Age and sex-associated differences in the relative abundance of multiple species of cytochrome P-450 system. Biochem Pharmacol 1985; 34: 1861–1864. 24 Suzuki T, Fujta S, Kitani K. The mechanism of senescence associated loss of sex difference in drug metabolizing enzyme activities in rats. In: L Vereczkey, K Magyar, eds. Cytochrome P-450, Biochemistry, biophysics and induction. Budapest: Akademia Kiado, 1985: 231–234. 25 Greenblatt DJ, Allen MD, Harmatz JS, et al. Diazepam disposition determinants. Clin Pharmacol Ther 1980; 27: 301–312. 26 Shader RI, Greenblatt DJ, Ciraulo DA, et al. Effect of age and sex on disposition of demethyldiazepam formed from its precursor clorazepate. Psychopharmacology 1981; 75: 193–197. 27 Sutter MA, Gibson G, Williamson LS, et al. Comparison of the hepatic mixed function oxidase systems of young, adult and old non-human primates (Macaca nemestrina). Biochem Pharmacol 1985; 34: 2983–2987. 28 Maloney AG, Schmucker DL, Vessey DS, et al. The effects of aging on the hepatic microsomal mixed function oxidase system of male and female monkeys. Hepatology 1986; 6: 000–000. 29 Cutler RG. Antioxidants and longevity. In: D Armstrong, RS Sohal, R Cutler, et al., eds. Free radicals in molecular biology, aging and disease. New York: Raven Press, 1984: 235–266. 30 Cutler RG. Antioxidants, aging and longevity. In: WA Pryoe, ed. Free radicals in biology, Vol VI. Orlando: Academic Press, 1984: 371–428. 31 James OFW, Rawlins MD, Woodhouse K. Lack of ageing effect on human microsomal monooxygenase enzyme activities and on inactivation pathways for reactive metabolic intermediates. In: K Kitani, ed. Liver and Aging–1982, Liver and drugs. Amsterdam: Elsevier Biomedical Press, 1982: 395–408. 32 Stohs SJ, Al-Turk WA, Angle CR. Glutathione S-transferase and glutathione reductase activities in hepatic and extrahepatic tissues of female mice as a function of age. Biochem Pharmacol 1982; 31: 2113–2116. 33 Kitahara A, Ebina T, Ishikawa T, et al. Changes in activities and molecular forms of rat hepatic drug metabolizing enzymes during aging. In: K Kitani, ed. Liver and aging–1982, Liver and drugs. Amsterdam: Elsevier Biomedical Press, 1982: 135–143. 34 Spearman ME, Leibman KC. The effects of aging on hepatic and pulmonary glutathione S-transferase activities in male and female Fischer 344 rats. Biochem Pharmacol 1984; 33: 1309–1313. 35 Spearman ME, Leibman KC. Aging selectively alters glutathine S-transferase isozyme concentrations in liver and lung cytosol. Drug Metab Dispos 1984; 12: 661–671. 36 Fujita S, Kitagawa H, Ishizawa H, et al. Age-associated alterations in hepatic glutathione-S-tansferase activities. Biochem Pharmacol 1985; 34: 3891–3894. 37 Kitani K. The role of the liver in the pharmacokinetic and pharmacodynamic alterations in the elderly. In: JL Waddington, K O'-Malley, eds. Therapeutics in the elderly. Amsterdam: Elsevier Scientific Publishers, 1985: 19–34. 38 Thompson EN, Williams R. Effect of age on liver function with particular referance to bromsulphalein excretion. Gut 1965; 6: 266–269. 39 Tauchi H, Sato T. Hepatic cells of the aged. In: K Kitani, ed. Liver and aging–1978, Amsterdam: Elsevier/North-Holland, 1978: 3–19. 40 Tauchi H. Cytomorphological studies of aging. Asian Med J 1984; 27: 741–760. 41 Anderson KE, Kappas A. Diet regulates drug and hormone metabolism in humans: experimental findings and clinical implications. In: J Caldwell, GD Paulson, eds. Foreign compounds metabolism. London: Taylor & Francis, 1984: 299–308. 42 Renton KW, Peterson TC. The influence of infection on the metabolism of foreign compounds. In: J Caldwell, GD Paulson, eds. Foreign compounds metabolism. London: Taylor & Francis, 1984: 289–298. 43 Feuer G, Carcinogenesis and cytochrome P-450. In: L Vereczkey, K Magyar, eds. Cytochrome P-450, biochemistry, biophysics and induction. Budapest: Akademia Kiado, 1985: 509–515. 44 Castleden CM. The use of hypnotics in elderly patients with impaired liver function. In: K Kitani, ed. Liver and aging–1982, Liver and drugs. Amsterdam: Elsevier Biomedical Press, 1982: 331–346. 45 Aoba A, Yamaguchi N, Shibata M, et al. Plama neuroleptic levels in the elderly patients on propericiazine therapy–Possible role of morbidity. Arch Gerontol Geriatr 1986 (in press). 46 Reidenberg MM, Levy M, Warner H, et al. Relationship between diazepam dose, plasma level, age and central nervous system depression. Clin Pharmacol Ther 1978; 23: 371–374. 47 Castleden CM, George CF, Marcer D, et al. Increased sensitivity to nitrazepam in old age. Br Med J 1977; 1: 10–12. 48 Stevenson IH. Drugs for the elderly. In: L Lemberger, MM Reidenberg, eds. Proc of the Second World Congress on Clinical Pharmacology, Washington, D.C.: American Society of Pharmacology and Experimental Therapy 1984: 64–73. 49 Kitani K, Masuda Y, Sato Y, et al. Increased anticonvulsant effect of phenytoin in aging BDF1 mice. J Pharmacol Exp Ther 1984; 229: 231–236. Citing Literature Volume6, Issue2March/April 1986Pages 316-319 ReferencesRelatedInformation" @default.
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