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• W2040254781 endingPage "016015" @default.
• W2040254781 startingPage "016015" @default.
• W2040254781 abstract "Interneurons coupled by both electrical gap-junctions (GJs) and chemical GABAergic synapses are major components of forebrain networks. However, their contributions to the generation of specific activity patterns, and their overall contributions to network function, remain poorly understood. Here we demonstrate, using computational methods, that the topological properties of interneuron networks can elicit a wide range of activity dynamics, and either prevent or permit local pattern formation. We systematically varied the topology of GJ and inhibitory chemical synapses within simulated networks, by changing connection types from local to random, and changing the total number of connections. As previously observed we found that randomly coupled GJs lead to globally synchronous activity. In contrast, we found that local GJ connectivity may govern the formation of highly spatially heterogeneous activity states. These states are inherently temporally unstable when the input is uniformly random, but can rapidly stabilize when the network detects correlations or asymmetries in the inputs. We show a correspondence between this feature of network activity and experimental observations of transient stabilization of striatal fast-spiking interneurons (FSIs), in electrophysiological recordings from rats performing a simple decision-making task. We suggest that local GJ coupling enables an active search-and-select function of striatal FSIs, which contributes to the overall role of cortical-basal ganglia circuits in decision-making." @default.
• W2040254781 created "2016-06-24" @default.
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• W2040254781 creator A5049737503 @default.
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• W2040254781 date "2010-03-12" @default.
• W2040254781 modified "2023-09-25" @default.
• W2040254781 title "Local dynamics of gap-junction-coupled interneuron networks" @default.
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• W2040254781 doi "https://doi.org/10.1088/1478-3975/7/1/016015" @default.
• W2040254781 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2896010" @default.
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