Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040257071> ?p ?o ?g. }
- W2040257071 endingPage "113" @default.
- W2040257071 startingPage "99" @default.
- W2040257071 abstract "Parkinsons disease (PD) is characterized clinically by resting tremor, rigidity, bradykinesia and postural instability due to progressive and selective loss of dopamine neurons in the ventral substantia nigra, with the presence of ubiquitinated protein deposits called Lewy bodies in the neurons. The pathoetiology of cell death in PD is incompletely understood and evidence implicates impaired mitochondrial complex I function, altered intracellular redox state, activation of proapoptotic factors and dysfunction of ubiquitinproteasome pathway. Now it is believed that genetic aberration, an environmental toxin or combination of both leads to a cascade of events culminating in the destruction of myelinated brainstem catecholaminergic neurons. Also the role of production of significant levels of abnormal proteins, which may misfold, aggregate and interfere with intracellular processes causing cytotoxicity has recently been hypothesized. In this article, the diverse pieces of evidence that have linked the various factors responsible for the pathophysiology of PD are reviewed with special emphasis to various candidate genes and proteins. Furthermore, the present therapeutic strategies and futuristic approaches for the pharmacotherapy of PD are critically discussed. Keywords: Parkinson's disease., lewy bodies, protein aggregation, pathophysiology, α-Synuclein, Parkin, Mitochondrial dysfunction" @default.
- W2040257071 created "2016-06-24" @default.
- W2040257071 creator A5034882909 @default.
- W2040257071 creator A5047073012 @default.
- W2040257071 creator A5071137594 @default.
- W2040257071 creator A5072115423 @default.
- W2040257071 date "2007-06-01" @default.
- W2040257071 modified "2023-09-26" @default.
- W2040257071 title "Parkinsons Disease: Genetics and Beyond" @default.
- W2040257071 cites W1206235977 @default.
- W2040257071 cites W1484252393 @default.
- W2040257071 cites W1496790952 @default.
- W2040257071 cites W1497064282 @default.
- W2040257071 cites W1517181973 @default.
- W2040257071 cites W1521854746 @default.
- W2040257071 cites W1527671059 @default.
- W2040257071 cites W1529474377 @default.
- W2040257071 cites W1530609782 @default.
- W2040257071 cites W1540436551 @default.
- W2040257071 cites W15418036 @default.
- W2040257071 cites W1545110321 @default.
- W2040257071 cites W1591724033 @default.
- W2040257071 cites W1603797935 @default.
- W2040257071 cites W1618846043 @default.
- W2040257071 cites W1642086117 @default.
- W2040257071 cites W1780139514 @default.
- W2040257071 cites W1781217464 @default.
- W2040257071 cites W1782287000 @default.
- W2040257071 cites W1923453730 @default.
- W2040257071 cites W1930841657 @default.
- W2040257071 cites W1965778124 @default.
- W2040257071 cites W1967773307 @default.
- W2040257071 cites W1968259213 @default.
- W2040257071 cites W1968957266 @default.
- W2040257071 cites W1969017404 @default.
- W2040257071 cites W1969800514 @default.
- W2040257071 cites W1970341001 @default.
- W2040257071 cites W1972097907 @default.
- W2040257071 cites W1972534455 @default.
- W2040257071 cites W1972939055 @default.
- W2040257071 cites W1972958434 @default.
- W2040257071 cites W1973300926 @default.
- W2040257071 cites W1973977165 @default.
- W2040257071 cites W1975188689 @default.
- W2040257071 cites W1976345822 @default.
- W2040257071 cites W1977166619 @default.
- W2040257071 cites W1977817124 @default.
- W2040257071 cites W1978062231 @default.
- W2040257071 cites W1979217137 @default.
- W2040257071 cites W1979318528 @default.
- W2040257071 cites W1984767115 @default.
- W2040257071 cites W1985321201 @default.
- W2040257071 cites W1985416646 @default.
- W2040257071 cites W1986188355 @default.
- W2040257071 cites W1986216002 @default.
- W2040257071 cites W1987041769 @default.
- W2040257071 cites W1987086879 @default.
- W2040257071 cites W1988949963 @default.
- W2040257071 cites W1989078232 @default.
- W2040257071 cites W1990158123 @default.
- W2040257071 cites W1991241547 @default.
- W2040257071 cites W1992253341 @default.
- W2040257071 cites W1995623204 @default.
- W2040257071 cites W1996001974 @default.
- W2040257071 cites W1996630962 @default.
- W2040257071 cites W1997833423 @default.
- W2040257071 cites W1999159261 @default.
- W2040257071 cites W2001751413 @default.
- W2040257071 cites W2002506451 @default.
- W2040257071 cites W2003376886 @default.
- W2040257071 cites W2005043001 @default.
- W2040257071 cites W2005379695 @default.
- W2040257071 cites W2008455214 @default.
- W2040257071 cites W2008748100 @default.
- W2040257071 cites W2008784665 @default.
- W2040257071 cites W2008827081 @default.
- W2040257071 cites W2009021103 @default.
- W2040257071 cites W2010577688 @default.
- W2040257071 cites W2011805483 @default.
- W2040257071 cites W2013047529 @default.
- W2040257071 cites W2013313629 @default.
- W2040257071 cites W2015363963 @default.
- W2040257071 cites W2017314199 @default.
- W2040257071 cites W2018481846 @default.
- W2040257071 cites W2019677819 @default.
- W2040257071 cites W2020351832 @default.
- W2040257071 cites W2020796799 @default.
- W2040257071 cites W2021242983 @default.
- W2040257071 cites W2022762621 @default.
- W2040257071 cites W2023245921 @default.
- W2040257071 cites W2023765475 @default.
- W2040257071 cites W2025145394 @default.
- W2040257071 cites W2025266279 @default.
- W2040257071 cites W2025469506 @default.
- W2040257071 cites W2026333065 @default.
- W2040257071 cites W2027649342 @default.
- W2040257071 cites W2028904494 @default.
- W2040257071 cites W2029000167 @default.