Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040257986> ?p ?o ?g. }
- W2040257986 endingPage "1698" @default.
- W2040257986 startingPage "1689" @default.
- W2040257986 abstract "We evaluated the immunohistochemical intensities of α-synuclein, phosphorylated α-synuclein (p-syn), dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32), calbindin-D 28k, calpain-cleaved carboxy-terminal 150-kDa spectrin fragment, and tyrosine hydroxylase in multiple system atrophy (MSA). The caudate head, anterior putamen, posterior putamen, substantia nigra, pontine nucleus, and cerebellar cortex from six MSA brains, six age-matched disease control brains (amyotrophic lateral sclerosis), and five control brains were processed for immunostaining by standard methods. Immunostaining for α-synuclein, p-syn, or both was increased in all areas examined in oligodendrocytes in MSA. Immunostaining for DARPP-32 and calbindin-D 28k was most prominently decreased in the posterior putamen, where neuronal loss was most prominent. Immunostaining for DARPP-32 and calbindin-D 28k was also diminished in the anterior putamen and caudate head, where neuronal loss was less prominent or absent. Calbindin immunostaining was also decreased in the dorsal tier of the substantia nigra and cerebellar cortex. Loss of immunostaining for DARPP-32 and calbindin-D 28k compared with that of neurons indicates calcium toxicity and disturbance of the phosphorylated state of proteins as relatively early events in the pathogenesis of MSA." @default.
- W2040257986 created "2016-06-24" @default.
- W2040257986 creator A5019994309 @default.
- W2040257986 creator A5020560198 @default.
- W2040257986 creator A5023317571 @default.
- W2040257986 creator A5025586479 @default.
- W2040257986 creator A5033227340 @default.
- W2040257986 creator A5040667714 @default.
- W2040257986 creator A5044022978 @default.
- W2040257986 creator A5049405145 @default.
- W2040257986 creator A5051335083 @default.
- W2040257986 creator A5057196849 @default.
- W2040257986 creator A5058996203 @default.
- W2040257986 creator A5070436055 @default.
- W2040257986 creator A5071195473 @default.
- W2040257986 creator A5081359917 @default.
- W2040257986 creator A5082083783 @default.
- W2040257986 date "2013-05-29" @default.
- W2040257986 modified "2023-09-27" @default.
- W2040257986 title "Loss of DARPP-32 and calbindin in multiple system atrophy" @default.
- W2040257986 cites W1518531861 @default.
- W2040257986 cites W1539309411 @default.
- W2040257986 cites W1643311486 @default.
- W2040257986 cites W1965866489 @default.
- W2040257986 cites W1977776486 @default.
- W2040257986 cites W1979100924 @default.
- W2040257986 cites W1982247983 @default.
- W2040257986 cites W1989999317 @default.
- W2040257986 cites W2006570692 @default.
- W2040257986 cites W2014602692 @default.
- W2040257986 cites W2017279410 @default.
- W2040257986 cites W2020174502 @default.
- W2040257986 cites W2029290999 @default.
- W2040257986 cites W2032053668 @default.
- W2040257986 cites W2039568351 @default.
- W2040257986 cites W2041507837 @default.
- W2040257986 cites W2041633486 @default.
- W2040257986 cites W2045737102 @default.
- W2040257986 cites W2049936588 @default.
- W2040257986 cites W2054145158 @default.
- W2040257986 cites W2057654544 @default.
- W2040257986 cites W2072902719 @default.
- W2040257986 cites W2083412737 @default.
- W2040257986 cites W2085486463 @default.
- W2040257986 cites W2087739393 @default.
- W2040257986 cites W2090048744 @default.
- W2040257986 cites W2108279879 @default.
- W2040257986 cites W2111901536 @default.
- W2040257986 cites W2133014807 @default.
- W2040257986 cites W2143547926 @default.
- W2040257986 cites W2168423079 @default.
- W2040257986 cites W2171123963 @default.
- W2040257986 cites W2326448721 @default.
- W2040257986 doi "https://doi.org/10.1007/s00702-013-1039-4" @default.
- W2040257986 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3834182" @default.
- W2040257986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23715974" @default.
- W2040257986 hasPublicationYear "2013" @default.
- W2040257986 type Work @default.
- W2040257986 sameAs 2040257986 @default.
- W2040257986 citedByCount "9" @default.
- W2040257986 countsByYear W20402579862014 @default.
- W2040257986 countsByYear W20402579862016 @default.
- W2040257986 countsByYear W20402579862019 @default.
- W2040257986 countsByYear W20402579862020 @default.
- W2040257986 countsByYear W20402579862021 @default.
- W2040257986 countsByYear W20402579862022 @default.
- W2040257986 countsByYear W20402579862023 @default.
- W2040257986 crossrefType "journal-article" @default.
- W2040257986 hasAuthorship W2040257986A5019994309 @default.
- W2040257986 hasAuthorship W2040257986A5020560198 @default.
- W2040257986 hasAuthorship W2040257986A5023317571 @default.
- W2040257986 hasAuthorship W2040257986A5025586479 @default.
- W2040257986 hasAuthorship W2040257986A5033227340 @default.
- W2040257986 hasAuthorship W2040257986A5040667714 @default.
- W2040257986 hasAuthorship W2040257986A5044022978 @default.
- W2040257986 hasAuthorship W2040257986A5049405145 @default.
- W2040257986 hasAuthorship W2040257986A5051335083 @default.
- W2040257986 hasAuthorship W2040257986A5057196849 @default.
- W2040257986 hasAuthorship W2040257986A5058996203 @default.
- W2040257986 hasAuthorship W2040257986A5070436055 @default.
- W2040257986 hasAuthorship W2040257986A5071195473 @default.
- W2040257986 hasAuthorship W2040257986A5081359917 @default.
- W2040257986 hasAuthorship W2040257986A5082083783 @default.
- W2040257986 hasBestOaLocation W20402579861 @default.
- W2040257986 hasConcept C126322002 @default.
- W2040257986 hasConcept C134018914 @default.
- W2040257986 hasConcept C137183658 @default.
- W2040257986 hasConcept C142724271 @default.
- W2040257986 hasConcept C159167319 @default.
- W2040257986 hasConcept C204232928 @default.
- W2040257986 hasConcept C26265296 @default.
- W2040257986 hasConcept C2779714222 @default.
- W2040257986 hasConcept C2780938664 @default.
- W2040257986 hasConcept C4224716 @default.
- W2040257986 hasConcept C513476851 @default.
- W2040257986 hasConcept C71924100 @default.
- W2040257986 hasConcept C86803240 @default.
- W2040257986 hasConceptScore W2040257986C126322002 @default.