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- W2040258375 abstract "Abstract Oxaloacetate was determined in pooled hearts instantly deep-frozen in situ from four groups of rats: normal or chronic alloxan-diabetic, each subdivided into fed or 24-h starved animals. The mean oxaloacetate level was significantly raised in the starved rats, both normal and diabetic. These data were compared to oxaloacetate values calculated in two separate ways, on the basis of the simultaneously-determined levels of the reactants of (i) the lactate and malate dehydrogenase systems, and (ii) the glutamate-oxaloacetate transaminase system in the same experiments. The mean determined and mean calculated values of oxaloacetate corresponded well in all groups and a correlation analysis confirmed a highly significant positive correlation in normal rats, but in diabetic animals only oxaloacetate calculations based on the glutamate-oxaloacetate transaminase system were correlated significantly with the determined values. The mass-action ratios for the glutamate-oxaloacetate transaminase system compared well with the thermodynamic equilibrium constant in all experimental groups, in spite of significant changes in level of the individual reactants (especially glutamate), as compared to the values in fed, normal rats." @default.
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- W2040258375 date "1972-08-01" @default.
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- W2040258375 title "The myocardial oxaloacetate level in normal and chronic alloxan-diabetic rats in vivo" @default.
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- W2040258375 doi "https://doi.org/10.1016/0022-2828(72)90085-5" @default.
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