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• W2040258601 endingPage "2507" @default.
• W2040258601 startingPage "2498" @default.
• W2040258601 abstract "IL-12 is important for Th1 differentiation. Myeloid-derived antigen-presenting cells (APC) such as monocytes, macrophages (Mϕ) and dendritic cells (DC) are believed to be major sources of IL-12 in vivo. We have compared IL-12 production of fresh monocytes with Mϕ differentiated in vitro using macrophage colony-stimulating factor (M-CSF) or human plasma, and in vitro generated dendritic cells, since these differentiated cell types represent APC at sites of antigen challenge. Macrophages stimulated with lipopolysaccharide (LPS) or heat-killed Listeria monocytogenes in the presence or absence of IFN-γ produced minimal IL-12 p70 by comparison with DC or monocytes, despite comparable production of TNF-α. M-CSF-induced Mϕ produced low levels of IL-10 constitutively and high levels after stimulation with LPS, but neutralization of IL-10 did not augment Mϕ IL-12 production. Exposure of Mϕ to TNF-α, granulocyte-macrophage CSF or IFN-γ did not substantially up-regulate IL-12. Therefore M-CSF induces a differentiated Mϕ phenotype in which IL-12 production is down-regulated, perhaps irreversibly. This may be the default pathway for monocyte-Mϕ development in the absence of inflammation." @default.
• W2040258601 created "2016-06-24" @default.
• W2040258601 creator A5003671742 @default.
• W2040258601 creator A5046780897 @default.
• W2040258601 creator A5057580992 @default.
• W2040258601 date "1998-08-01" @default.
• W2040258601 modified "2023-09-29" @default.
• W2040258601 title "Human macrophages inducedin vitroby macrophage colony-stimulating factor are deficient in IL-12 production" @default.
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• W2040258601 doi "https://doi.org/10.1002/(sici)1521-4141(199808)28:08<2498::aid-immu2498>3.0.co;2-q" @default.
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• W2040258601 hasPublicationYear "1998" @default.
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