Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040259039> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2040259039 endingPage "1154" @default.
- W2040259039 startingPage "1148" @default.
- W2040259039 abstract "A novel method of screening for immunomodulating substances is developed employing lymphocytes and three mitogens. Concanavalin A (Con A) and phytohemagglutinin (PHA) are applied as T cell specific stimulants and lipopolysaccharide (LPS) as a B cell specific stimulant respectively. The lymphocytes obtained from mouse spleen are cultured with an antibiotic or a sample extract in the presence or absence of mitogen for three days and pulsed with [3H]thymidine for five hours before harvest. Differential effects of a sample compound on [3H]thymidine incorporation by the activated and quiescent lymphocytes are scored. In this procedure most of the tested antibiotics or chemical compounds with different mode of actions show non-specific effects. Cyclosporin A, a potent immunosuppressive substance, suppresses both Con A and PHA responses more extensively than LPS response and quiescent cell growth, and two cytochrome bc1 complex inhibitors, funiculosin and antimycin A3, are less suppressive to PHA response than to the others. The present system was also applied to the methanol extracts of the culture broths prepared from the type strains of Actinomycetes and Penicillium." @default.
- W2040259039 created "2016-06-24" @default.
- W2040259039 creator A5009787961 @default.
- W2040259039 creator A5035443911 @default.
- W2040259039 creator A5044957935 @default.
- W2040259039 creator A5062905036 @default.
- W2040259039 creator A5086841862 @default.
- W2040259039 date "1986-01-01" @default.
- W2040259039 modified "2023-10-03" @default.
- W2040259039 title "A novel method of screening for immunomodulating substances, establishment of an assay system and its application to culture broths of microorganisms." @default.
- W2040259039 cites W1481092787 @default.
- W2040259039 cites W1504800642 @default.
- W2040259039 cites W1539061345 @default.
- W2040259039 cites W155647446 @default.
- W2040259039 cites W163125452 @default.
- W2040259039 cites W1850346488 @default.
- W2040259039 cites W1977030532 @default.
- W2040259039 cites W2002146198 @default.
- W2040259039 cites W201659892 @default.
- W2040259039 cites W2030185252 @default.
- W2040259039 cites W2046148051 @default.
- W2040259039 cites W2050746500 @default.
- W2040259039 cites W2070447912 @default.
- W2040259039 cites W2077173353 @default.
- W2040259039 cites W2077704631 @default.
- W2040259039 cites W2112166400 @default.
- W2040259039 cites W2120331741 @default.
- W2040259039 cites W2137078804 @default.
- W2040259039 cites W2151724911 @default.
- W2040259039 cites W2159892244 @default.
- W2040259039 cites W2616279752 @default.
- W2040259039 doi "https://doi.org/10.7164/antibiotics.39.1148" @default.
- W2040259039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3759665" @default.
- W2040259039 hasPublicationYear "1986" @default.
- W2040259039 type Work @default.
- W2040259039 sameAs 2040259039 @default.
- W2040259039 citedByCount "49" @default.
- W2040259039 countsByYear W20402590392012 @default.
- W2040259039 countsByYear W20402590392013 @default.
- W2040259039 countsByYear W20402590392014 @default.
- W2040259039 countsByYear W20402590392015 @default.
- W2040259039 countsByYear W20402590392017 @default.
- W2040259039 countsByYear W20402590392019 @default.
- W2040259039 countsByYear W20402590392022 @default.
- W2040259039 countsByYear W20402590392023 @default.
- W2040259039 crossrefType "journal-article" @default.
- W2040259039 hasAuthorship W2040259039A5009787961 @default.
- W2040259039 hasAuthorship W2040259039A5035443911 @default.
- W2040259039 hasAuthorship W2040259039A5044957935 @default.
- W2040259039 hasAuthorship W2040259039A5062905036 @default.
- W2040259039 hasAuthorship W2040259039A5086841862 @default.
- W2040259039 hasBestOaLocation W20402590391 @default.
- W2040259039 hasConcept C153911025 @default.
- W2040259039 hasConcept C185592680 @default.
- W2040259039 hasConcept C19869320 @default.
- W2040259039 hasConcept C202751555 @default.
- W2040259039 hasConcept C203014093 @default.
- W2040259039 hasConcept C2777108182 @default.
- W2040259039 hasConcept C2778754761 @default.
- W2040259039 hasConcept C54355233 @default.
- W2040259039 hasConcept C55493867 @default.
- W2040259039 hasConcept C81885089 @default.
- W2040259039 hasConcept C86803240 @default.
- W2040259039 hasConcept C89423630 @default.
- W2040259039 hasConcept C98274493 @default.
- W2040259039 hasConceptScore W2040259039C153911025 @default.
- W2040259039 hasConceptScore W2040259039C185592680 @default.
- W2040259039 hasConceptScore W2040259039C19869320 @default.
- W2040259039 hasConceptScore W2040259039C202751555 @default.
- W2040259039 hasConceptScore W2040259039C203014093 @default.
- W2040259039 hasConceptScore W2040259039C2777108182 @default.
- W2040259039 hasConceptScore W2040259039C2778754761 @default.
- W2040259039 hasConceptScore W2040259039C54355233 @default.
- W2040259039 hasConceptScore W2040259039C55493867 @default.
- W2040259039 hasConceptScore W2040259039C81885089 @default.
- W2040259039 hasConceptScore W2040259039C86803240 @default.
- W2040259039 hasConceptScore W2040259039C89423630 @default.
- W2040259039 hasConceptScore W2040259039C98274493 @default.
- W2040259039 hasIssue "8" @default.
- W2040259039 hasLocation W20402590391 @default.
- W2040259039 hasLocation W20402590392 @default.
- W2040259039 hasOpenAccess W2040259039 @default.
- W2040259039 hasPrimaryLocation W20402590391 @default.
- W2040259039 hasRelatedWork W1523509875 @default.
- W2040259039 hasRelatedWork W1863774198 @default.
- W2040259039 hasRelatedWork W1980857822 @default.
- W2040259039 hasRelatedWork W1997902062 @default.
- W2040259039 hasRelatedWork W2016292453 @default.
- W2040259039 hasRelatedWork W2087511880 @default.
- W2040259039 hasRelatedWork W2169375472 @default.
- W2040259039 hasRelatedWork W2261943241 @default.
- W2040259039 hasRelatedWork W2395579238 @default.
- W2040259039 hasRelatedWork W2412963476 @default.
- W2040259039 hasVolume "39" @default.
- W2040259039 isParatext "false" @default.
- W2040259039 isRetracted "false" @default.
- W2040259039 magId "2040259039" @default.
- W2040259039 workType "article" @default.