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• W2040264973 abstract "Inositol 1,4,5‐trisphosphate (IP 3 ) induces a release of Ca 2+ from vacuolar membrane vesicles of Saccharomyces cerevisiae . The amount released is dependent on IP 3 concentration (concentration for half maximal effect, K m apparent = 0.4 μM). Myo ‐inositol, and inositol 1,4‐bisphosphate up to 50 μM have no effect on Ca 2+ levels in the vesicles. The IP 3 ‐induced Ca 2+ release is blocked by dantrolene and 8‐( N , N ‐diethylamino)‐octyl 3,4,5‐trimethoxybenzoate‐HCl (TMB‐8), which are known to block Ca 2+ release from Ca 2+ stores in animal cells. IP 3 ‐induced release of Ca 2+ also occurs when Ca 2+ is accumulated by means of an artificial pH gradient, indicating that the effect of IP 3 is not due to an effect on the vacuolar H + ‐ATPase. The IP 3 ‐induced Ca 2+ release is not accompanied by a change in the pH gradient, which indicates that it is not due to a reversal of the Ca 2+ /nH + antiport or to a decrease in ΔpH by IP 3 . The present results suggest that IP 3 may act as a second messenger in the mobilization of Ca 2+ in yeast cells. As in plant cells, the vacuolar membrane of yeast seems to contain a Ca 2+ channel, which can be opened by IP 3 . In this respect the vacuole could function as an IP 3 ‐regulated intracellular Ca 2+ store, equivalent to the endoplasmic‐ and sarcoplasmic reticulum in animal cells, and play a role in Ca 2+ ‐dependent signal transduction in yeast cells." @default.
• W2040264973 created "2016-06-24" @default.
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• W2040264973 date "1993-05-24" @default.
• W2040264973 modified "2023-10-15" @default.
• W2040264973 title "Inositol 1,4,5‐trisphosphate releases Ca²⁺ from vacuolar membrane vesicles of <i>Saccharomyces cerevisiae</i>" @default.
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• W2040264973 doi "https://doi.org/10.1016/0014-5793(93)81460-h" @default.
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