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• W2040274499 endingPage "136" @default.
• W2040274499 startingPage "125" @default.
• W2040274499 abstract "Human adenovirus (Ad) types 2, 3 and 12 are known to interact with cell surface integrins αvβ3 and αvβ5 through an RGD motif carried by the penton base. This interaction is thought to augment virus entry after initial contact between the fiber and specific receptor(s). Ad40 and Ad41 are the only members of the human subgroup F adenoviruses. The penton base protein sequence of one Ad40 strain is known to carry the motif RGAD rather than RGD, suggesting that not all human adenoviruses use the above integrins for cell entry. We confirmed that different genomic variants of Ad40 all carry an RGAD motif on the penton base, and found that the Ad41 prototype and several other genomic variants of Ad41 carry the motif IGDD in place of RGAD or RGD. This region is most likely exposed on the Ad41 particle, but attempts to block Ad41 infectivity using a homologous peptide were unsuccessful. Infectivity of an Ad41 preparation as measured by fluorescent focus assay in A549 cells was highly dependent on the length of the adsorption period, indicating that fiber-mediated attachment is inefficient in these cells. Moreover, Ad41 virions adsorbed for 1 h were internalized in a semi-linear fashion over 8 h. This inefficient uptake may be a direct consequence of independence of subgroup F adenoviruses from αvβ3 and αvβ5 integrin-mediated endocytosis. Ad40 and Ad41 may thus have lost or may never have developed a dependence on the penton base RGD motif for entry." @default.
• W2040274499 created "2016-06-24" @default.
• W2040274499 creator A5045043764 @default.
• W2040274499 creator A5081317499 @default.
• W2040274499 date "1999-11-01" @default.
• W2040274499 modified "2023-09-27" @default.
• W2040274499 title "Adenovirus type 41 lacks an RGD αv-integrin binding motif on the penton base and undergoes delayed uptake in A549 cells" @default.
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• W2040274499 doi "https://doi.org/10.1016/s0168-1702(99)00087-8" @default.
• W2040274499 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10518709" @default.
• W2040274499 hasPublicationYear "1999" @default.
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