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- W2040275272 abstract "Heat shock proteins are expressed in response to cellular stress and can protect cells from further stress and facilitate recovery. Heat shock protein 27 is of particular interest because it has been implicated in a range of protective roles including protein chaperoning, stabilising elements of the cytoskeleton and as an active inhibitor of apoptosis. In the present study, we have examined the potential of administration of exogenous HSP27 to confer protection against KA-induced neuronal cell death in vivo. We aimed to exploit the neurotropic specificity of herpes simplex virus-1 based virus vectors, which have been rendered replication-incompetent, to infect neurons of the hippocampus. The systemic administration of kainic acid, an analogue of glutamate, causes seizures resulting in neuronal damage and is an established animal model of epilepsy. Neuron loss is particularly prominent in the hippocampus and the mode of death is at least partly apoptotic in nature. We show that the overexpression of HSP27 in these neurons can significantly augment their survival following kainic acid administration. In contrast, injection of a control virus expressing β-galactosidase does not confer protection. This is the first time that protection by exogenously expressed HSP27 has been demonstrated in an in vivo model of neuronal cell death." @default.
- W2040275272 created "2016-06-24" @default.
- W2040275272 creator A5002956062 @default.
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- W2040275272 creator A5053679530 @default.
- W2040275272 creator A5065095747 @default.
- W2040275272 date "2003-03-01" @default.
- W2040275272 modified "2023-10-05" @default.
- W2040275272 title "Heat shock protein 27 delivered via a herpes simplex virus vector can protect neurons of the hippocampus against kainic-acid-induced cell loss" @default.
- W2040275272 cites W1481540262 @default.
- W2040275272 cites W1490731141 @default.
- W2040275272 cites W1526199338 @default.
- W2040275272 cites W1537274817 @default.
- W2040275272 cites W1540426161 @default.
- W2040275272 cites W1733825645 @default.
- W2040275272 cites W1861851844 @default.
- W2040275272 cites W1904784968 @default.
- W2040275272 cites W1952459948 @default.
- W2040275272 cites W1965053184 @default.
- W2040275272 cites W1967524093 @default.
- W2040275272 cites W1967710456 @default.
- W2040275272 cites W1970111956 @default.
- W2040275272 cites W1974832634 @default.
- W2040275272 cites W1975807829 @default.
- W2040275272 cites W1976462601 @default.
- W2040275272 cites W1976598822 @default.
- W2040275272 cites W1978489370 @default.
- W2040275272 cites W1983420534 @default.
- W2040275272 cites W1984277765 @default.
- W2040275272 cites W1986207229 @default.
- W2040275272 cites W1987766146 @default.
- W2040275272 cites W1988338629 @default.
- W2040275272 cites W1988812998 @default.
- W2040275272 cites W1994773533 @default.
- W2040275272 cites W2007501972 @default.
- W2040275272 cites W2008343355 @default.
- W2040275272 cites W2009660306 @default.
- W2040275272 cites W2011265783 @default.
- W2040275272 cites W2011893442 @default.
- W2040275272 cites W2014147440 @default.
- W2040275272 cites W2014396854 @default.
- W2040275272 cites W2014470637 @default.
- W2040275272 cites W2016141321 @default.
- W2040275272 cites W2018147265 @default.
- W2040275272 cites W2028340150 @default.
- W2040275272 cites W2030428515 @default.
- W2040275272 cites W2031065479 @default.
- W2040275272 cites W2032288826 @default.
- W2040275272 cites W2035862839 @default.
- W2040275272 cites W2037302221 @default.
- W2040275272 cites W2042441031 @default.
- W2040275272 cites W2043834895 @default.
- W2040275272 cites W2044007161 @default.
- W2040275272 cites W2046015107 @default.
- W2040275272 cites W2052264856 @default.
- W2040275272 cites W2056073162 @default.
- W2040275272 cites W2060644195 @default.
- W2040275272 cites W2062362233 @default.
- W2040275272 cites W2068688726 @default.
- W2040275272 cites W2072319452 @default.
- W2040275272 cites W2073423744 @default.
- W2040275272 cites W2076846187 @default.
- W2040275272 cites W2077754511 @default.
- W2040275272 cites W2078630510 @default.
- W2040275272 cites W2085251042 @default.
- W2040275272 cites W2089118425 @default.
- W2040275272 cites W2090980940 @default.
- W2040275272 cites W2092700031 @default.
- W2040275272 cites W2093473585 @default.
- W2040275272 cites W2103072852 @default.
- W2040275272 cites W2103946141 @default.
- W2040275272 cites W2107789276 @default.
- W2040275272 cites W2111858669 @default.
- W2040275272 cites W2112360818 @default.
- W2040275272 cites W2117998622 @default.
- W2040275272 cites W2129801260 @default.
- W2040275272 cites W2140735579 @default.
- W2040275272 cites W2140834315 @default.
- W2040275272 cites W2141261198 @default.
- W2040275272 cites W2142181775 @default.
- W2040275272 cites W2154904733 @default.
- W2040275272 cites W2156110752 @default.
- W2040275272 cites W2161872417 @default.
- W2040275272 cites W2166730435 @default.
- W2040275272 cites W2171417441 @default.
- W2040275272 cites W2210469066 @default.
- W2040275272 cites W2330499395 @default.
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- W2040275272 doi "https://doi.org/10.1016/s0169-328x(02)00692-7" @default.
- W2040275272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12654509" @default.
- W2040275272 hasPublicationYear "2003" @default.
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