FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040276875> ?p ?o ?g. }

• W2040276875 endingPage "584" @default.
• W2040276875 startingPage "577" @default.
• W2040276875 abstract "In spite of aggressive surgery, irradiation and/or chemotherapy, treatment of malignant gliomas remains a major challenge in adults and children due to high treatment failure. We have demonstrated significant cell lysis and antitumour activity of the E1B-55 kDa-gene-deleted adenovirus ONYX-015 (dl1520, CI-1042; ONYX Pharmaceuticals) in subcutaneous human malignant glioma xenografts deriving from primary tumours. Here, we show the combined efficacy of this oncolytic therapy with radiation therapy. Total body irradiation (5 Gy) of athymic nude mice prior to intratumoral injections of ONYX-015 1 x 10(8) PFU daily for 5 consecutive days yielded additive tumour growth delays in the p53 mutant xenograft IGRG88. Radiation therapy was potentiated in the p53 functional tumour IGRG121 with a 'subtherapeutic' dose of 1 x 10(7) PFU daily for 5 consecutive days, inducing significant tumour growth delay, 90% tumour regression and 50% tumour-free survivors 4 months after treatment. These potentiating effects were not due to increased adenoviral infectivity or replication. Furthermore, cell lysis and induction of apoptosis, the major mechanisms for adenoviral antitumour activity, did not play a major role in the combined treatment strategy. Interestingly, the oncolytic adenovirus seemed to accelerate radiation-induced tumour fibrosis. Potentiating antitumour activity suggests the development of this combined treatment for these highly malignant tumours." @default.
• W2040276875 created "2016-06-24" @default.
• W2040276875 creator A5002357765 @default.
• W2040276875 creator A5007454863 @default.
• W2040276875 creator A5031557667 @default.
• W2040276875 creator A5039709555 @default.
• W2040276875 creator A5044195657 @default.
• W2040276875 creator A5051922909 @default.
• W2040276875 creator A5056220279 @default.
• W2040276875 creator A5067202962 @default.
• W2040276875 creator A5068706237 @default.
• W2040276875 creator A5082404845 @default.
• W2040276875 date "2003-07-29" @default.
• W2040276875 modified "2023-10-09" @default.
• W2040276875 title "Potentiation of radiation therapy by the oncolytic adenovirus dl1520 (ONYX-015) in human malignant glioma xenografts" @default.
• W2040276875 cites W1498486272 @default.
• W2040276875 cites W1567384233 @default.
• W2040276875 cites W1579361447 @default.
• W2040276875 cites W1582164157 @default.
• W2040276875 cites W1808107661 @default.
• W2040276875 cites W1901035215 @default.
• W2040276875 cites W1993034243 @default.
• W2040276875 cites W2011206688 @default.
• W2040276875 cites W2015435526 @default.
• W2040276875 cites W2015560811 @default.
• W2040276875 cites W2051758487 @default.
• W2040276875 cites W2065392104 @default.
• W2040276875 cites W2084679824 @default.
• W2040276875 cites W2109126615 @default.
• W2040276875 cites W2128366838 @default.
• W2040276875 cites W2130641534 @default.
• W2040276875 cites W2133481877 @default.
• W2040276875 cites W2151242353 @default.
• W2040276875 cites W2397737370 @default.
• W2040276875 cites W2404586247 @default.
• W2040276875 cites W2465290011 @default.
• W2040276875 cites W2479044294 @default.
• W2040276875 doi "https://doi.org/10.1038/sj.bjc.6601102" @default.
• W2040276875 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2394372" @default.
• W2040276875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12888833" @default.
• W2040276875 hasPublicationYear "2003" @default.
• W2040276875 type Work @default.
• W2040276875 sameAs 2040276875 @default.
• W2040276875 citedByCount "85" @default.
• W2040276875 countsByYear W20402768752012 @default.
• W2040276875 countsByYear W20402768752013 @default.
• W2040276875 countsByYear W20402768752014 @default.
• W2040276875 countsByYear W20402768752015 @default.
• W2040276875 countsByYear W20402768752016 @default.
• W2040276875 countsByYear W20402768752017 @default.
• W2040276875 countsByYear W20402768752018 @default.
• W2040276875 countsByYear W20402768752019 @default.
• W2040276875 countsByYear W20402768752020 @default.
• W2040276875 countsByYear W20402768752021 @default.
• W2040276875 countsByYear W20402768752022 @default.
• W2040276875 countsByYear W20402768752023 @default.
• W2040276875 crossrefType "journal-article" @default.
• W2040276875 hasAuthorship W2040276875A5002357765 @default.
• W2040276875 hasAuthorship W2040276875A5007454863 @default.
• W2040276875 hasAuthorship W2040276875A5031557667 @default.
• W2040276875 hasAuthorship W2040276875A5039709555 @default.
• W2040276875 hasAuthorship W2040276875A5044195657 @default.
• W2040276875 hasAuthorship W2040276875A5051922909 @default.
• W2040276875 hasAuthorship W2040276875A5056220279 @default.
• W2040276875 hasAuthorship W2040276875A5067202962 @default.
• W2040276875 hasAuthorship W2040276875A5068706237 @default.
• W2040276875 hasAuthorship W2040276875A5082404845 @default.
• W2040276875 hasBestOaLocation W20402768751 @default.
• W2040276875 hasConcept C104317684 @default.
• W2040276875 hasConcept C111599444 @default.
• W2040276875 hasConcept C126322002 @default.
• W2040276875 hasConcept C190283241 @default.
• W2040276875 hasConcept C2776694085 @default.
• W2040276875 hasConcept C2776954459 @default.
• W2040276875 hasConcept C2777283488 @default.
• W2040276875 hasConcept C2778227246 @default.
• W2040276875 hasConcept C3020616263 @default.
• W2040276875 hasConcept C502942594 @default.
• W2040276875 hasConcept C509974204 @default.
• W2040276875 hasConcept C55493867 @default.
• W2040276875 hasConcept C71924100 @default.
• W2040276875 hasConcept C82210918 @default.
• W2040276875 hasConcept C86803240 @default.
• W2040276875 hasConceptScore W2040276875C104317684 @default.
• W2040276875 hasConceptScore W2040276875C111599444 @default.
• W2040276875 hasConceptScore W2040276875C126322002 @default.
• W2040276875 hasConceptScore W2040276875C190283241 @default.
• W2040276875 hasConceptScore W2040276875C2776694085 @default.
• W2040276875 hasConceptScore W2040276875C2776954459 @default.
• W2040276875 hasConceptScore W2040276875C2777283488 @default.
• W2040276875 hasConceptScore W2040276875C2778227246 @default.
• W2040276875 hasConceptScore W2040276875C3020616263 @default.
• W2040276875 hasConceptScore W2040276875C502942594 @default.
• W2040276875 hasConceptScore W2040276875C509974204 @default.
• W2040276875 hasConceptScore W2040276875C55493867 @default.
• W2040276875 hasConceptScore W2040276875C71924100 @default.
• W2040276875 hasConceptScore W2040276875C82210918 @default.
• W2040276875 hasConceptScore W2040276875C86803240 @default.

• next