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• W2040281282 abstract "Objective To investigate the effect of 17β-oestradiol ophthalmic drops in comparison with a traditional Design Randomised prospective trial. Setting Menopause clinic. Participants Eighty-four postmenopausal women suffering from keratoconjunctivitis sicca and necessitating a hormone replacement therapy (HRT) for general climacteric symptoms. Methods The women were randomised into two groups and were given 17β-oestradiol eye drops (n=42, group 1) or a tear substitute (n=42, group 2). Both groups received a systemic HRT. Main outcome measures A Schirmer's test was performed immediately before the beginning of therapy and after four months. In addition, eye symptoms were assessed using a visual analogue scale. Results A comparison of visual analogue scores at four months in the women who received 17β-oestradiol eye drops versus those who received a tear substitute demonstrated a statistically significant difference in all observed ocular symptoms (P<0.0001) The Schirmer's test revealed a significant difference of results before and after treatment in the oestradiol group (P<0.0001) while in group 2 no significant difference was found. Conclusions Our study demonstrates that topical oestrogen is successful in treating keratoconjunctivitis sicca while it seems that the blood-eye barrier prevents systemic oestrogens from acting on the conjunctivae." @default.
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• W2040281282 date "1998-01-01" @default.
• W2040281282 modified "2023-09-25" @default.
• W2040281282 title "Treatment of menopausal keratoconjunctivitis sicca with topical oestradiol" @default.
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• W2040281282 doi "https://doi.org/10.1111/j.1471-0528.1998.tb09358.x" @default.
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