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• W2040285285 endingPage "70" @default.
• W2040285285 startingPage "63" @default.
• W2040285285 abstract "The activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy, however, the mechanism remains unclear. Rat models of cardiac hypertrophy were created with transaortic constriction (TAC) to investigate the mechanistic role of AMPK involved. RT-PCR and Western blot analyses indicated that hypertrophy marker genes ANP and β-MHC expression were up-regulated in the myocardium of TAC rats. We also observed that the expressions of peroxisome proliferator-activated receptor-α (PPARα) and its target genes, carnitine palmitoyl transferase-І (CPT-І) and medium-chain acyl-COA dehydrogenases (MCAD), were down-regulated, and the fatty acid oxidation was decreased in TAC rats. Treatment of TAC animals with 5-aminoimidazole 1 carboxamide ribonucleoside (AICAR, 0.5 mg/g body wt), a specific activator of AMPK, inhibited cardiac hypertrophy in TAC and reversed PPARα, CPT-I and MCAD expression and fatty acid oxidation. Similar observations were made in hypertrophied cardiomyocytes induced by phenylephrine in vitro. Treatment of hypertrophied cardiomyocytes with Compound C, a specific AMPK inhibitor, showed an effect opposite to that of AICAR. The effect of AICAR on cardiac hypertrophy was blocked after PPARα was silenced by transfection of cardiomyocytes with PPARα-siRNA. Luciferase activity assay suggested that AICAR elevates PPARα transcriptional activity. These results indicate that AMPK plays an important role in the inhibition of cardiac hypertrophy by activating the PPARα signaling pathway." @default.
• W2040285285 created "2016-06-24" @default.
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• W2040285285 date "2009-10-01" @default.
• W2040285285 modified "2023-10-18" @default.
• W2040285285 title "Adenosine monophosphate-activated protein kinase inhibits cardiac hypertrophy through reactivating peroxisome proliferator-activated receptor-α signaling pathway" @default.
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• W2040285285 doi "https://doi.org/10.1016/j.ejphar.2009.08.024" @default.
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