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• W2040286039 abstract "Four toxic polypeptidic fractions (TdF-I–IV) were purified from the venom of the Venezuelan scorpion Tityus discrepans by means of gel filtration on Sephadex® G-50. The peptides have mol. wts of approx. 6000 and normalized elution volumes (Vn = Elution volume/Total column volume) of: TdF-I = 0.27 (0.26, 0.28), n = 13; TdF-II = 0.40 (0.39,0.41), n = 15; TdF-III = 0.57 (0.56, 0.59), n = 14, and TdF-IV = 0.68 (0.67, 0.70), n = 13 (median and its 95% confidence interval, n = number of elutions used to calculate the median). Mice (white, male, 16–19 g, IVIC strain) were injected with these fractions and sacrificed 48 hr later. No toxicity was observed when fraction I (0.93 μg/g mice) or IV (2.51 μg/g mice) was injected i.p. into mice. TdF-II (9 to 50 μg/g mice) produced sialorrhea, dyspnea and death 1 hr after i.p. injection. Light microscopy of the pancreas revealed that TdF-III (3.42 μg/g mice) produced structural modifications such as acinar cell vacuolization, degranulation and interstitial swelling; these changes are characteristic of acute pancreatitis. No effects on the islets of Langerhans or the pancreatic ducts were observed. TdF-III had no overt muscarinic effects when injected i.p. into mice. On the neuromuscular preparation of the frog (Hyla crepitans) TdF-I blocked neuromuscular transmission at the postsynaptic membrane; TdF-II depolarized the muscle membrane by opening sodium channels and TdF-IV prolonged action potentials, suggesting potassium channel blockage." @default.
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• W2040286039 date "1995-03-01" @default.
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• W2040286039 title "Presence of curarizing polypeptides and a pancreatitis-inducing fraction without muscarinic effects in the venom of the venezuelan scorpion tityus discrepans (karsch)" @default.
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• W2040286039 doi "https://doi.org/10.1016/0041-0101(94)00171-4" @default.
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