Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040287500> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2040287500 endingPage "228" @default.
- W2040287500 startingPage "221" @default.
- W2040287500 abstract "After exposure of H460 cells to an increasing concentrations of cis-diammine-dichloroplatinum(II) (cisplatin, CDDP) for 6 months, cisplatin resistant cells were isolated (H460/CIS). The biologic behaviors of H460 and H460/CIS cells were tested using animal experiments. Only the resistant cells developed lung metastases despite cisplatin treatment. The characteristics of H460/CIS cells are as follows, MTT analyses revealed that H460/CIS cells were markedly resistant to cisplatin compared with their parental cells. Also, H460/CIS cells exhibited cross-resistance to DNA damaging agents such as doxorubicin (DXR) and etoposide. Cisplatin treatment dramatically increased p53 expression in parental cells but not in H460/CIS cells which expressed basal levels of p53. Without cisplatin treatment, Bcl-2 and Bax were expressed in H460/CIS cells, but not in parental cell. Our data suggested that p53, Bax and Bcl-2 were up-regulated in H460/CIS cells. These changes could explain some of the mechanisms of cisplatin resistance. Thus, H460/CIS could be useful to investigate the mechanisms of drug resistance to cisplatin including apoptotic gene expressions conferring drug resistance, thereby making progress in the treatment of cisplatin-resistant tumor cells." @default.
- W2040287500 created "2016-06-24" @default.
- W2040287500 creator A5010364211 @default.
- W2040287500 creator A5015414564 @default.
- W2040287500 creator A5031678345 @default.
- W2040287500 creator A5045941652 @default.
- W2040287500 creator A5082630538 @default.
- W2040287500 date "2001-08-01" @default.
- W2040287500 modified "2023-10-16" @default.
- W2040287500 title "In vitro establishment of cis-diammine-dichloroplatinum(II) resistant lung cancer cell line and modulation of apoptotic gene expression as a mechanism of resistant phenotype" @default.
- W2040287500 cites W1935990934 @default.
- W2040287500 cites W1964226854 @default.
- W2040287500 cites W1965510904 @default.
- W2040287500 cites W1979487870 @default.
- W2040287500 cites W1980635047 @default.
- W2040287500 cites W1987344600 @default.
- W2040287500 cites W1993732814 @default.
- W2040287500 cites W2004969496 @default.
- W2040287500 cites W2010407192 @default.
- W2040287500 cites W2013925593 @default.
- W2040287500 cites W2028044172 @default.
- W2040287500 cites W2035222065 @default.
- W2040287500 cites W2036102152 @default.
- W2040287500 cites W2052644553 @default.
- W2040287500 cites W2057272164 @default.
- W2040287500 cites W2059306650 @default.
- W2040287500 cites W2075265441 @default.
- W2040287500 cites W2076149108 @default.
- W2040287500 cites W2078144803 @default.
- W2040287500 cites W2095725874 @default.
- W2040287500 cites W2150389963 @default.
- W2040287500 cites W2158157639 @default.
- W2040287500 cites W2164961251 @default.
- W2040287500 doi "https://doi.org/10.1016/s0169-5002(01)00205-7" @default.
- W2040287500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11551417" @default.
- W2040287500 hasPublicationYear "2001" @default.
- W2040287500 type Work @default.
- W2040287500 sameAs 2040287500 @default.
- W2040287500 citedByCount "16" @default.
- W2040287500 countsByYear W20402875002012 @default.
- W2040287500 countsByYear W20402875002014 @default.
- W2040287500 countsByYear W20402875002018 @default.
- W2040287500 countsByYear W20402875002019 @default.
- W2040287500 crossrefType "journal-article" @default.
- W2040287500 hasAuthorship W2040287500A5010364211 @default.
- W2040287500 hasAuthorship W2040287500A5015414564 @default.
- W2040287500 hasAuthorship W2040287500A5031678345 @default.
- W2040287500 hasAuthorship W2040287500A5045941652 @default.
- W2040287500 hasAuthorship W2040287500A5082630538 @default.
- W2040287500 hasConcept C104317684 @default.
- W2040287500 hasConcept C114851261 @default.
- W2040287500 hasConcept C127716648 @default.
- W2040287500 hasConcept C153911025 @default.
- W2040287500 hasConcept C190283241 @default.
- W2040287500 hasConcept C202751555 @default.
- W2040287500 hasConcept C2776694085 @default.
- W2040287500 hasConcept C2778119113 @default.
- W2040287500 hasConcept C2778239845 @default.
- W2040287500 hasConcept C502942594 @default.
- W2040287500 hasConcept C54355233 @default.
- W2040287500 hasConcept C71924100 @default.
- W2040287500 hasConcept C81885089 @default.
- W2040287500 hasConcept C86803240 @default.
- W2040287500 hasConceptScore W2040287500C104317684 @default.
- W2040287500 hasConceptScore W2040287500C114851261 @default.
- W2040287500 hasConceptScore W2040287500C127716648 @default.
- W2040287500 hasConceptScore W2040287500C153911025 @default.
- W2040287500 hasConceptScore W2040287500C190283241 @default.
- W2040287500 hasConceptScore W2040287500C202751555 @default.
- W2040287500 hasConceptScore W2040287500C2776694085 @default.
- W2040287500 hasConceptScore W2040287500C2778119113 @default.
- W2040287500 hasConceptScore W2040287500C2778239845 @default.
- W2040287500 hasConceptScore W2040287500C502942594 @default.
- W2040287500 hasConceptScore W2040287500C54355233 @default.
- W2040287500 hasConceptScore W2040287500C71924100 @default.
- W2040287500 hasConceptScore W2040287500C81885089 @default.
- W2040287500 hasConceptScore W2040287500C86803240 @default.
- W2040287500 hasIssue "2-3" @default.
- W2040287500 hasLocation W20402875001 @default.
- W2040287500 hasLocation W20402875002 @default.
- W2040287500 hasOpenAccess W2040287500 @default.
- W2040287500 hasPrimaryLocation W20402875001 @default.
- W2040287500 hasRelatedWork W1972108695 @default.
- W2040287500 hasRelatedWork W1974720886 @default.
- W2040287500 hasRelatedWork W2030883789 @default.
- W2040287500 hasRelatedWork W2062908963 @default.
- W2040287500 hasRelatedWork W2158954526 @default.
- W2040287500 hasRelatedWork W2370283463 @default.
- W2040287500 hasRelatedWork W2391989703 @default.
- W2040287500 hasRelatedWork W2410227504 @default.
- W2040287500 hasRelatedWork W2425688305 @default.
- W2040287500 hasRelatedWork W8414141 @default.
- W2040287500 hasVolume "33" @default.
- W2040287500 isParatext "false" @default.
- W2040287500 isRetracted "false" @default.
- W2040287500 magId "2040287500" @default.
- W2040287500 workType "article" @default.